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Articles Published Processes
8/27/2024 3:11:19 PM | Browse: 130 | Download: 714
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Received |
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2024-03-06 11:33 |
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Peer-Review Started |
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2024-03-06 11:33 |
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First Decision by Editorial Office Director |
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2024-05-08 03:12 |
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Return for Revision |
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2024-05-08 03:12 |
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Revised |
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2024-06-04 12:33 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-06-25 06:46 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-07-02 07:23 |
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Articles in Press |
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2024-07-02 07:23 |
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Edit the Manuscript by Language Editor |
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2024-07-30 02:05 |
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Typeset the Manuscript |
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2024-07-31 11:00 |
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Publish the Manuscript Online |
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2024-08-27 15:11 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Basic Study |
| Article Title |
Corilagin alleviates podocyte injury in diabetic nephropathy by regulating autophagy via the SIRT1-AMPK pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu Lou, Yu-Ting Luan, Wen-Qing Rong and Yun Gai |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shanghai Pudong New Area Leading Talents Training Program Project |
PWR12020-02 |
| Shanghai Pudong New Area Excellent Young Medical Talents Training Program Project |
PWRq2023-40 |
| Shanghai Pudong New Area Health and Family Planning Scientific Research Project |
PW2022A-91 |
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| Corresponding Author |
Yun Gai, PhD, Chief Physician, Department of General Practice (Including Medical Oncology), Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No. 358 Datong Road, Shanghai 200137, China. gaiyunlucky@163.com |
| Key Words |
Corilagin; Podocyte injury; Diabetic nephropathy; Autophagy; High-glucose; SIRT1-AMPK pathway |
| Core Tip |
This study explored the protective roles of Corilagin (Cor) against podocyte injury in diabetic nephropathy (DN). The Cor treatment markedly attenuated fasting blood glucose, glycosylated hemoglobin, triglycerides, total cholesterol, increased nephrin and podocin expression, reduced apoptosis rate, inhibited inflammatory cytokines expression and oxidative stress. In addition, Cor contributed to improving the SIRT1 and AMPK expression, inhibited reactive oxygen species and oxidative stress and elevated autophagy in high-glucose-induced podocytes. Thus, Cor might be a potential therapeutic agent for the treatment and clinical management of DN. |
| Publish Date |
2024-08-27 15:11 |
| Citation |
Lou Y, Luan YT, Rong WQ, Gai Y. Corilagin alleviates podocyte injury in diabetic nephropathy by regulating autophagy via the SIRT1-AMPK pathway. World J Diabetes 2024; 15(9): 1916-1931 |
| URL |
https://www.wjgnet.com/1948-9358/full/v15/i9/1916.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v15.i9.1916 |
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