Publication Name	World Journal of Methodology
Manuscript ID	93854
Country	India

Received	2024-03-06 16:29
Peer-Review Started	2024-03-06 16:29
To Make the First Decision
Return for Revision	2024-04-11 03:09
Revised	2024-04-23 15:57
Second Decision	2024-05-11 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-05-11 10:51
Articles in Press	2024-05-11 10:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-06-12 00:40
Publish the Manuscript Online	2024-06-25 09:25

ISSN	2222-0682 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Randomized Clinical Trial
Article Title	Botulinum toxin type A for treating chronic low back pain: A double blinded randomized control study
Manuscript Source	Invited Manuscript
All Author List	Mantu Jain, Shahnawaz Khan, Paulson Varghese, Sujit Kumar Tripathy and Manaswini Mangaraj
ORCID	Author(s) ORCID Number Paulson Varghese http://orcid.org/0000-0002-2323-4980 Sujit Kumar Tripathy http://orcid.org/0000-0003-0179-9910 Manaswini Mangaraj http://orcid.org/0000-0003-0179-9912
Funding Agency and Grant Number	Funding Agency Grant Number All India Institute of Medical Sciences Bhubaneswar Research Grant AIIMS/BBSR/RS/2022/372
Corresponding Author	Sujit Kumar Tripathy, MS, Professor, Department of Orthopaedics, All India Institute of Medical Sciences, Sijua, Patrapada, Bhubaneswar 751019, Odisha, India. ortho_sujit@aiimsbhubaneswar.edu.in
Key Words	Botulinum toxin type A; Chronic low back pain; Randomized control study; Double-blinded; Pain management; Therapeutic efficacy
Core Tip	This randomized clinical trial investigated Botulinum toxin type A (BoNT-A) for treating chronic low back pain (CLBP) in adults aged 18-60 years old with symptoms persisting for over six months. Participants were divided into two groups: one receiving BoNT-A and the other a placebo, with outcomes measured using the Visual Analog Scale for pain and the Oswestry Disability Index (ODI) for disability. After two months, both groups showed pain reduction, but only the decrease in ODI scores was statistically significant (but clinically insignificant). Ultimately, BoNT-A did not demonstrate a short-term advantage over placebo in reducing pain or improving disability scores in CLBP patients.
Publish Date	2024-06-25 09:25
Citation	<p>Jain M, Khan S, Varghese P, Tripathy SK, Mangaraj M. Botulinum toxin type A for treating chronic low back pain: A double blinded randomized control study. <i>World J Methodol</i> 2024; 14(3): 93854</p>
URL	https://www.wjgnet.com/2222-0682/full/v14/i3/93854.htm
DOI	https://dx.doi.org/10.5662/wjm.v14.i3.93854

Full Article (PDF)	WJM-14-93854-with-cover.pdf
CONSORT 2010 Statement	93854-CONSORT-2010-statement.pdf
Manuscript File	93854_Auto_Edited-JLW.docx
Answering Reviewers	93854-answering-reviewers.pdf
Audio Core Tip	93854-audio.mp3
Biostatistics Review Certificate	93854-biostatistics-statement.pdf
Clinical Trial Registration Statement	93854-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form	93854-conflict-of-interest-statement.pdf
Copyright License Agreement	93854-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	93854-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	93854-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	93854-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	93854-non-native-speakers.pdf
Peer-review Report	93854-peer-reviews.pdf
Scientific Misconduct Check	93854-scientific-misconduct-check.png
Scientific Editor Work List	93854-scientific-editor-work-list.pdf
CrossCheck Report	93854-crosscheck-report.png
CrossCheck Report	93854-crosscheck-report.pdf