| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
MicroRNA-31 expression in colorectal serrated pathway progression
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hironori Aoki, Katsuhiko Nosho, Hisayoshi Igarashi, Miki Ito, Kei Mitsuhashi, Takafumi Naito, Eiichiro Yamamoto, Tokuma Tanuma, Masafumi Nomura, Hiroyuki Maguchi, Toshiya Shinohara, Hiromu Suzuki, Hiroyuki Yamamoto and Yasuhisa Shinomura |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research |
23790800 (to Nosho K) |
| A-STEP (Adaptable and Seamless Technology Transfer Program through Target-driven R and D) |
to Nosho K |
|
| Corresponding Author |
Katsuhiko Nosho, MD, PhD, Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, S-1, W-16, Chou-ku, Sapporo 060-8543, Japan. nosho@sapmed.ac.jp |
| Key Words |
BRAF; Colorectal carcinoma; MicroRNA-31; MLH1; microsatellite instability; Serrated pathway |
| Core Tip |
At a follow-up colonoscopy, we observed the case of a 75-year-old man with a 7-mm flat-elevated lesion in the cecum. Because the flat-elevated area displayed serrated features, we diagnosed the lesion as an early invasive carcinoma with a hyperplastic polyp (HP) component. Higher microRNA-31 (miR-31) expression was observed in the carcinoma component (57-fold increase) and the HP component (8-fold increase) compared with the paired normal mucosa. This is the first case report of early invasive colorectal cancer with an HP component in which miR-31 expression was analyzed. Our results suggest that miR-31 may be an important molecule in serrated pathway progression. |
| Publish Date |
2014-09-18 19:50 |
| Citation |
Aoki H, Nosho K, Igarashi H, Ito M, Mitsuhashi K, Naito T, Yamamoto E, Tanuma T, Nomura M, Maguchi H, Shinohara T, Suzuki H, Yamamoto H, Shinomura Y. MicroRNA-31 expression in colorectal serrated pathway progression. World J Gastroenterol 2014; 20(34): 12346-12349 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i34/12346.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i34.12346 |
