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9/18/2014 7:49:00 PM | Browse: 451 | Download: 514
Publication Name World Journal of Gastroenterology
Manuscript ID 9387
Country/Territory Japan
Received
2014-02-12 04:20
Peer-Review Started
2014-02-12 10:15
To Make the First Decision
2014-03-13 19:01
Return for Revision
2014-03-20 09:40
Revised
2014-03-26 18:46
Second Decision
2014-05-26 16:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-05-26 16:54
Articles in Press
2014-05-26 17:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-08-28 11:47
Publish the Manuscript Online
2014-09-18 19:50
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Case Report
Article Title MicroRNA-31 expression in colorectal serrated pathway progression
Manuscript Source Unsolicited Manuscript
All Author List Hironori Aoki, Katsuhiko Nosho, Hisayoshi Igarashi, Miki Ito, Kei Mitsuhashi, Takafumi Naito, Eiichiro Yamamoto, Tokuma Tanuma, Masafumi Nomura, Hiroyuki Maguchi, Toshiya Shinohara, Hiromu Suzuki, Hiroyuki Yamamoto and Yasuhisa Shinomura
Funding Agency and Grant Number
Funding Agency Grant Number
Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research 23790800 (to Nosho K)
A-STEP (Adaptable and Seamless Technology Transfer Program through Target-driven R and D) to Nosho K
Corresponding author Katsuhiko Nosho, MD, PhD, Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, S-1, W-16, Chou-ku, Sapporo 060-8543, Japan. nosho@sapmed.ac.jp
Keywords BRAF; Colorectal carcinoma; MicroRNA-31; MLH1; microsatellite instability; Serrated pathway
Core Tip At a follow-up colonoscopy, we observed the case of a 75-year-old man with a 7-mm flat-elevated lesion in the cecum. Because the flat-elevated area displayed serrated features, we diagnosed the lesion as an early invasive carcinoma with a hyperplastic polyp (HP) component. Higher microRNA-31 (miR-31) expression was observed in the carcinoma component (57-fold increase) and the HP component (8-fold increase) compared with the paired normal mucosa. This is the first case report of early invasive colorectal cancer with an HP component in which miR-31 expression was analyzed. Our results suggest that miR-31 may be an important molecule in serrated pathway progression.
Publish Date 2014-09-18 19:50
Citation Aoki H, Nosho K, Igarashi H, Ito M, Mitsuhashi K, Naito T, Yamamoto E, Tanuma T, Nomura M, Maguchi H, Shinohara T, Suzuki H, Yamamoto H, Shinomura Y. MicroRNA-31 expression in colorectal serrated pathway progression. World J Gastroenterol 2014; 20(34): 12346-12349
Url http://www.wjgnet.com/1007-9327/full/v20/i34/12346.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i34.12346
Full Article (PDF) WJG-20-12346.pdf
Full Article (Word) WJG-20-12346.doc
Manuscript File 9387-Review.docx
Answering Reviewers 9387-Answering reviewers.pdf
Copyright License Agreement 9387-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 9387-Language certificate.pdf
Peer-review Report 9387-Peer review(s).pdf
Scientific Misconduct Check 9387-CrossCheck.jpg
Scientific Editor Work List 9387-Scientific editor work list.pdf