Publication Name	World Journal of Gastroenterology
Manuscript ID	9387
Country	Japan

Received	2014-02-12 04:20
Peer-Review Started	2014-02-12 10:15
First Decision by Editorial Office Director
Return for Revision	2014-03-20 09:40
Revised	2014-03-26 18:46
Publication Fee Transferred
Second Decision by Editor	2014-05-26 16:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-05-26 16:54
Articles in Press	2014-05-26 17:32
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-28 11:47
Publish the Manuscript Online	2014-09-18 19:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	MicroRNA-31 expression in colorectal serrated pathway progression
Manuscript Source	Unsolicited Manuscript
All Author List	Hironori Aoki, Katsuhiko Nosho, Hisayoshi Igarashi, Miki Ito, Kei Mitsuhashi, Takafumi Naito, Eiichiro Yamamoto, Tokuma Tanuma, Masafumi Nomura, Hiroyuki Maguchi, Toshiya Shinohara, Hiromu Suzuki, Hiroyuki Yamamoto and Yasuhisa Shinomura
Funding Agency and Grant Number	Funding Agency Grant Number Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research 23790800 (to Nosho K) A-STEP (Adaptable and Seamless Technology Transfer Program through Target-driven R and D) to Nosho K
Corresponding Author	Katsuhiko Nosho, MD, PhD, Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, S-1, W-16, Chou-ku, Sapporo 060-8543, Japan. nosho@sapmed.ac.jp
Key Words	BRAF; Colorectal carcinoma; MicroRNA-31; MLH1; microsatellite instability; Serrated pathway
Core Tip	At a follow-up colonoscopy, we observed the case of a 75-year-old man with a 7-mm flat-elevated lesion in the cecum. Because the flat-elevated area displayed serrated features, we diagnosed the lesion as an early invasive carcinoma with a hyperplastic polyp (HP) component. Higher microRNA-31 (miR-31) expression was observed in the carcinoma component (57-fold increase) and the HP component (8-fold increase) compared with the paired normal mucosa. This is the first case report of early invasive colorectal cancer with an HP component in which miR-31 expression was analyzed. Our results suggest that miR-31 may be an important molecule in serrated pathway progression.
Publish Date	2014-09-18 19:50
Citation	Aoki H, Nosho K, Igarashi H, Ito M, Mitsuhashi K, Naito T, Yamamoto E, Tanuma T, Nomura M, Maguchi H, Shinohara T, Suzuki H, Yamamoto H, Shinomura Y. MicroRNA-31 expression in colorectal serrated pathway progression. World J Gastroenterol 2014; 20(34): 12346-12349
URL	http://www.wjgnet.com/1007-9327/full/v20/i34/12346.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i34.12346

Full Article (PDF)	WJG-20-12346.pdf
Full Article (Word)	WJG-20-12346.doc