Publication Name	World Journal of Gastroenterology
Manuscript ID	93879
Country	Viet Nam

Received	2024-03-07 07:19
Peer-Review Started	2024-03-07 07:19
To Make the First Decision
Return for Revision	2024-08-22 04:42
Revised	2024-09-04 03:52
Second Decision	2024-10-16 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-16 07:26
Articles in Press	2024-10-16 07:26
Publication Fee Transferred	2024-10-16 08:41
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-23 07:45
Publish the Manuscript Online	2024-11-21 07:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Multi-clustering study on the association between human leukocyte antigen-DP-DQ and hepatitis B virus-related hepatocellular carcinoma and cirrhosis in Viet Nam
Manuscript Source	Unsolicited Manuscript
All Author List	Thuy Thu Nguyen, Tu Cam Ho, Huong Thi Thu Bui, Van-Khanh Tran and Tue Trong Nguyen
ORCID	Author(s) ORCID Number Thuy Thu Nguyen http://orcid.org/0000-0003-1306-6159 Tu Cam Ho http://orcid.org/0000-0001-8239-096X Huong Thi Thu Bui http://orcid.org/0000-0002-4101-5618 Van-Khanh Tran http://orcid.org/0000-0002-5059-8106 Tue Trong Nguyen http://orcid.org/0000-0002-5986-831X
Funding Agency and Grant Number	Funding Agency Grant Number National Foundation for Science and Technology Development (NAFOSTED)-Ministry of Science and Technology, Viet Nam 108.02-2019.307
Corresponding Author	Tue Trong Nguyen, Medical Technology Department, Hanoi Medical University, No. 1 Ton That Tung Street, Dong Da District, Hanoi 116177, Viet Nam. trongtue@hmu.edu.vn
Key Words	Human leukocyte antigen; Multi-clustering study; Hepatitis B virus; Hepatocellular carcinoma; Cirrhosis
Core Tip	A significant correlation was observed between Human leukocyte antigen (HLA)-DP-DQ polymorphisms and the risk of hepatitis B virus (HBV)-related liver cirrhosis (LC) and hepatocellular carcinoma (HCC). In this study, individuals with the HLA-DP and HLA-DQ genotypes were found to have a higher prevalence of LC and HCC. The hypothesis that HLA polymorphisms play a crucial role in the progression of HBV-related liver diseases has been confirmed. Specific HLA-DP and HLA-DQ alleles were associated with the risk of HBV-related LC and HCC. By delving into the genetic underpinnings of these diseases, we highlight the potential for developing personalized medical approaches and targeted therapies for affected individuals.
Publish Date	2024-11-21 07:04
Citation	<p>Nguyen TT, Ho TC, Bui HTT, Tran VK, Nguyen TT. Multi-clustering study on the association between human leukocyte antigen-DP-DQ and hepatitis B virus-related hepatocellular carcinoma and cirrhosis in Viet Nam. <i>World J Gastroenterol</i> 2024; 30(46): 4880-4903</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i46/4880.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i46.4880

Full Article (PDF)	WJG-30-4880-with-cover.pdf
STROBE Statement	93879-STROBE-statement.pdf
Manuscript File	93879_Auto_Edited_085402.docx
Answering Reviewers	93879-answering-reviewers.pdf
Audio Core Tip	93879-audio.m4a
Biostatistics Review Certificate	93879-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	93879-conflict-of-interest-statement.pdf
Copyright License Agreement	93879-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	93879-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	93879-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	93879-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	93879-non-native-speakers.pdf
Supplementary Material	93879-supplementary-material.pdf
Peer-review Report	93879-peer-reviews.pdf
Scientific Misconduct Check	93879-scientific-misconduct-check.png
Scientific Editor Work List	93879-scientific-editor-work-list.pdf
CrossCheck Report	93879-crosscheck-report.pdf