Publication Name	World Journal of Clinical Cases
Manuscript ID	93891
Country	China

Received	2024-03-07 09:07
Peer-Review Started	2024-03-07 09:07
To Make the First Decision
Return for Revision	2024-05-06 20:45
Revised	2024-05-18 12:33
Second Decision	2024-06-04 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-06-04 10:06
Articles in Press	2024-06-04 10:06
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-06-10 03:57
Typeset the Manuscript	2024-06-12 00:17
Publish the Manuscript Online	2024-07-01 06:03

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Case Report
Article Title	Pulsatile gonadotropin-releasing hormone therapy induces spermatogenesis in pituitary stalk interruption syndrome: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Jin-Long Xie, Hai-Ying Zhu, Yang Dong, Ping-Ping Sun, Dan-Dan Qi, Su-Xian Luan, Yan Zhang and Hua-Gang Ma
ORCID	Author(s) ORCID Number Hua-Gang Ma http://orcid.org/0009-0003-2116-1401
Funding Agency and Grant Number	Funding Agency Grant Number Weifang Fundamental Research Projects WFWSJK-2023-052
Corresponding Author	Hua-Gang Ma, PhD, Professor, The Reproductive Medicine Centre, Weifang People’s Hospital, No. 151 Guangwen Street, Weifang 261000, Shandong Province, China. mahuagang@126.com
Key Words	Pituitary stalk interruption syndrome; Hypogonadotropic hypogonadism; Spermatogenesis; Pulsatile gonadotropin-releasing hormone therapy; Case report
Core Tip	Pituitary stalk interruption syndrome (PSIS) is a rare anatomical defect affecting the pituitary gland, falling within the spectrum of holoprosencephaly phenotypes. In cases where fertility is a concern, treatment options typically involve pulsatile GnRH therapy and gonadotropin therapy. This case study highlights a patient with PSIS who initially did not respond to gonadotropin therapy but showed successful spermatogenesis upon switching to pulsatile GnRH therapy. Timely identification, accurate diagnosis, and tailored treatment play a vital role in enhancing the quality of life and fertility outcomes for individuals with PSIS.
Publish Date	2024-07-01 06:03
Citation	<p>Xie JL, Zhu HY, Dong Y, Sun PP, Qi DD, Luan SX, Zhang Y, Ma HG. Pulsatile gonadotropin-releasing hormone therapy induces spermatogenesis in pituitary stalk interruption syndrome: A case report and review of literature. <i>World J Clin Cases</i> 2024; 12(20): 4348-4356</p>
URL	https://www.wjgnet.com/2307-8960/full/v12/i20/4348.htm
DOI	https://dx.doi.org/10.12998/wjcc.v12.i20.4348

Full Article (PDF)	WJCC-12-4348-with-cover.pdf
CARE Checklist–2016	93891-CARE-Checklist-2016.pdf
Manuscript File	93891_Auto_Edited-LJH-JLW_WangTQ.docx
Answering Reviewers	93891-answering-reviewers.pdf
Audio Core Tip	93891-audio.mp3
Conflict-of-Interest Disclosure Form	93891-conflict-of-interest-statement.pdf
Copyright License Agreement	93891-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	93891-foundation-statement.pdf
Signed Consent for Treatment Form(s) or Document(s)	93891-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate	93891-non-native-speakers.pdf
Peer-review Report	93891-peer-reviews.pdf
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Scientific Editor Work List	93891-scientific-editor-work-list.pdf
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