Publication Name	World Journal of Clinical Cases
Manuscript ID	93946
Country	China

Received	2024-03-08 08:08
Peer-Review Started	2024-03-08 08:08
To Make the First Decision
Return for Revision	2024-05-09 23:42
Revised	2024-06-11 04:50
Second Decision	2024-06-26 02:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-06-26 09:32
Articles in Press	2024-06-26 09:32
Publication Fee Transferred	2024-06-29 03:13
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-07-03 09:12
Publish the Manuscript Online	2024-07-11 09:22

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Exploration of the complex origins of primary constipation
Manuscript Source	Unsolicited Manuscript
All Author List	Xing-Lin Zeng, Lian-Jun Zhu and Xiang-Dong Yang
ORCID	Author(s) ORCID Number Xing-Lin Zeng http://orcid.org/0009-0006-8424-5428 Xiang-Dong Yang http://orcid.org/0009-0007-5699-1949
Funding Agency and Grant Number
Corresponding Author	Xiang-Dong Yang, MM, Professor, Colorectal and Anal Surgery, Chengdu Anorectal Hospital, No. 152 Daqiang East Street, Taisheng South Road, Chengdu 610015, Sichuan Province, China. y-xd@vip.163.com
Key Words	Primary constipation; Pathogenesis factors; Treatment
Core Tip	The etiology of constipation is complex, involving a series of primary and secondary causes. Some of the primary factors reviewed in this paper include decreased interstitial cells of Cajal, altered colonic motility, enteric nervous system dysfunction, intestinal flora disturbances, and psychological influences. Clarifying the etiology of constipation can significantly facilitate the management of this disease through an interdisciplinary approach, incorporating dietary modifications, lifestyle changes, pharmacotherapy, and psychological interventions.
Publish Date	2024-07-11 09:22
Citation	<p>Zeng XL, Zhu LJ, Yang XD. Exploration of the complex origins of primary constipation. <i>World J Clin Cases</i> 2024; 12(24): 5476-5482</p>
URL	https://www.wjgnet.com/2307-8960/full/v12/i24/5476.htm
DOI	https://dx.doi.org/10.12998/wjcc.v12.i24.5476

Full Article (PDF)	WJCC-12-5476-with-cover.pdf
Manuscript File	93946_Auto_Edited-JLW.docx
Answering Reviewers	93946-answering-reviewers.pdf
Audio Core Tip	93946-audio.mp3
Conflict-of-Interest Disclosure Form	93946-conflict-of-interest-statement.pdf
Copyright License Agreement	93946-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	93946-non-native-speakers.pdf
Peer-review Report	93946-peer-reviews.pdf
Scientific Misconduct Check	93946-scientific-misconduct-check.png
Scientific Editor Work List	93946-scientific-editor-work-list.pdf
CrossCheck Report	93946-crosscheck-report.pdf