BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/16/2024 8:03:14 AM | Browse: 70 | Download: 254
 |
Received |
|
2024-03-21 13:28 |
|
Peer-Review Started |
|
2024-03-21 13:28 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2024-07-09 13:21 |
|
Revised |
|
2024-07-20 03:02 |
|
Second Decision |
|
2024-07-29 02:49 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2024-07-29 07:47 |
|
Articles in Press |
|
2024-07-29 07:47 |
|
Publication Fee Transferred |
|
2024-07-30 09:29 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2024-08-12 07:55 |
|
Publish the Manuscript Online |
|
2024-08-16 08:03 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Preparation of kakkatin derivatives and their anti-tumor activity
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-Ying Jiang, Hui-Hua Dong, Wen-Ting Zhou, Jia-Zi Luo, Xian Wei and Yan-Qiang Huang |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Xian Wei, PhD, Professor, Research Center for the Prevention and Treatment of Drug Resistant Microbial Infecting, The Youjiang Medical University for Nationalities, No. 98 ChengXiang Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. 27848258@qq.com |
| Key Words |
Kakkatin; Derivative; Hepatocellular carcinoma; Anti-tumor; Biological activity |
| Core Tip |
We synthesized a new kakkatin derivative [6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one (HK)] and explored its anti-tumor activity against liver cancer, gastric cancer and its potential mechanism of action. It was found that the synthesized HK increased the anti-hepatoma activity by nearly 30 times compared with kakkatin, but the inhibitory effect on gastric cancer MGC803 cells was not much different from that of kakkatin, indicating that the anti-tumor activity of HK may be more specific. PDE3B and NFKB1 proteins in the cAMP pathway are the targets of the HK on HCC SMMC-7721 cells. |
| Publish Date |
2024-08-16 08:03 |
| Citation |
<p>Jiang YY, Dong HH, Zhou WT, Luo JZ, Wei X, Huang YQ. Preparation of kakkatin derivatives and their anti-tumor activity. <i>World J Clin Oncol</i> 2024; 15(8): 1078-1091</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v15/i8/1078.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v15.i8.1078 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
