Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	94032
Country	China

Received	2024-03-10 11:07
Peer-Review Started	2024-03-10 11:07
To Make the First Decision
Return for Revision	2024-04-29 07:14
Revised	2024-05-09 13:17
Second Decision	2024-05-20 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-05-20 06:29
Articles in Press	2024-05-20 06:29
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-05-27 14:34
Typeset the Manuscript	2024-06-05 06:34
Publish the Manuscript Online	2024-07-12 15:55

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Basic Study
Article Title	N6-methyladenosine modification of hypoxia-inducible factor-1α regulated Helicobacter pylori-infected gastric cancer via the PI3K/AKT pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Tong-Yan An, Quan-Man Hu, Peng Ni, Yan-Qiao Hua, Di Wang, Guang-Cai Duan, Shuai-Yin Chen and Bin Jia
ORCID	Author(s) ORCID Number Shuai-Yin Chen http://orcid.org/0000-0001-6129-0310 Bin Jia http://orcid.org/0009-0006-5090-9062
Funding Agency and Grant Number	Funding Agency Grant Number The Key Research and Development and Promotion Special Project of Henan Province 222102310069 National Natural Science Foundation of China 82073618
Corresponding Author	Shuai-Yin Chen, MD, PhD, Associate Professor, Department of Epidemiology, College of Public Health, Zhengzhou University, No. 100 Kexue Road, Zhengzhou 450001, Henan Province, China. sychen@zzu.edu.cn
Key Words	Helicobacter pylori; Gastric cancer; Methyltransferase-like protein 14; Hypoxia-inducible factor-1α; N6-methyladenosine; PI3K/AKT pathway
Core Tip	Helicobacter pylori (H. pylori) is the most significant risk factor for gastric cancer. Studies have shown that hypoxia-inducible factor-1α (HIF-1α) is highly expressed in tumors, enabling them to adapt to hypoxic microenvironment and promoting malignant behavior. However, the pathogenesis of HIF-1α in H. pylori infection remains unclear. We found that methyltransferase-like protein 14 acts as a molecular switch of H. pylori-induced HIF-1α and regulates malignant behavior through the PI3K/AKT pathway. This study is the first to explore the mechanism by which H. pylori induces HIF-1α from the perspective of N6-methyladenosine modification.
Publish Date	2024-07-12 15:55
Citation	<p>An TY, Hu QM, Ni P, Hua YQ, Wang D, Duan GC, Chen SY, Jia B. N6-methyladenosine modification of hypoxia-inducible factor-1α regulated Helicobacter pylori-infected gastric cancer via the PI3K/AKT pathway. <i>World J Gastrointest Oncol</i> 2024; 16(7): 3270-3283</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i7/3270.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i7.3270

Full Article (PDF)	WJGO-16-3270-with-cover.pdf
The ARRIVE Guidelines	94032-The-ARRIVE-Guidelines.pdf
Manuscript File	94032_Auto_Edited-YJP_WangTQ.docx
Answering Reviewers	94032-answering-reviewers.pdf
Audio Core Tip	94032-audio.mp3
Biostatistics Review Certificate	94032-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	94032-conflict-of-interest-statement.pdf
Copyright License Agreement	94032-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	94032-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	94032-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	94032-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	94032-non-native-speakers.pdf
Supplementary Material	94032-supplementary-material.pdf
Peer-review Report	94032-peer-reviews.pdf
Scientific Misconduct Check	94032-scientific-misconduct-check.png
Scientific Editor Work List	94032-scientific-editor-work-list.pdf