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Articles Published Processes
7/12/2024 3:55:59 PM | Browse: 255 | Download: 1224
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Received |
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2024-03-10 11:07 |
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Peer-Review Started |
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2024-03-10 11:07 |
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First Decision by Editorial Office Director |
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2024-04-29 07:14 |
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Return for Revision |
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2024-04-29 07:14 |
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Revised |
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2024-05-09 13:17 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-05-20 02:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-05-20 06:29 |
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Articles in Press |
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2024-05-20 06:29 |
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Edit the Manuscript by Language Editor |
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2024-05-27 14:34 |
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Typeset the Manuscript |
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2024-06-05 06:34 |
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Publish the Manuscript Online |
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2024-07-12 15:55 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
N6-methyladenosine modification of hypoxia-inducible factor-1α regulated Helicobacter pylori-infected gastric cancer via the PI3K/AKT pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tong-Yan An, Quan-Man Hu, Peng Ni, Yan-Qiao Hua, Di Wang, Guang-Cai Duan, Shuai-Yin Chen and Bin Jia |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Key Research and Development and Promotion Special Project of Henan Province |
222102310069 |
| National Natural Science Foundation of China |
82073618 |
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| Corresponding Author |
Shuai-Yin Chen, MD, PhD, Associate Professor, Department of Epidemiology, College of Public Health, Zhengzhou University, No. 100 Kexue Road, Zhengzhou 450001, Henan Province, China. sychen@zzu.edu.cn |
| Key Words |
Helicobacter pylori; Gastric cancer; Methyltransferase-like protein 14; Hypoxia-inducible factor-1α; N6-methyladenosine; PI3K/AKT pathway |
| Core Tip |
Helicobacter pylori (H. pylori) is the most significant risk factor for gastric cancer. Studies have shown that hypoxia-inducible factor-1α (HIF-1α) is highly expressed in tumors, enabling them to adapt to hypoxic microenvironment and promoting malignant behavior. However, the pathogenesis of HIF-1α in H. pylori infection remains unclear. We found that methyltransferase-like protein 14 acts as a molecular switch of H. pylori-induced HIF-1α and regulates malignant behavior through the PI3K/AKT pathway. This study is the first to explore the mechanism by which H. pylori induces HIF-1α from the perspective of N6-methyladenosine modification. |
| Publish Date |
2024-07-12 15:55 |
| Citation |
An TY, Hu QM, Ni P, Hua YQ, Wang D, Duan GC, Chen SY, Jia B. N6-methyladenosine modification of hypoxia-inducible factor-1α regulated Helicobacter pylori-infected gastric cancer via the PI3K/AKT pathway. World J Gastrointest Oncol 2024; 16(7): 3270-3283
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| URL |
https://www.wjgnet.com/1948-5204/full/v16/i7/3270.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i7.3270 |
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