Publication Name	World Journal of Gastroenterology
Manuscript ID	941
Country	Poland

Received	2012-10-29 16:26
Peer-Review Started	2012-10-29 22:28
To Make the First Decision	2012-11-14 10:04
Return for Revision	2012-11-15 10:41
Revised	2013-01-11 17:01
Second Decision	2013-04-18 16:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-04-19 06:14
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-05 21:17
Publish the Manuscript Online	2013-06-20 16:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Evaluation of enterochromaffin cells and melatonin secretion exponents in ulcerative colitis
Manuscript Source	Invited Manuscript
All Author List	Cezary Chojnacki, Maria Wiśniewska-Jarosińska, Grażyna Kulig, Ireneusz Majsterek, Russel J Reiter and Jan Chojnacki
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Science and High Education of Poland NN402 4221/38
Corresponding Author	Jan Chojnacki, MD, PhD, Department of Gastroenterology, Medical University of Lodzpl, Hallera 1, 90-647 Lodz, Poland. gastrologia@umed.lodz.pl
Key Words	Enterochromaffin cells; 5-hydroxyindole-O-methyltransferase; 6-sulfatoxymelatonin; Ulcerative proctitis; Ulcerative colitis
Core Tip	In the gastrointestinal tract melatonin is secreted mainly by enterochromaffin cells (EC). It appears that hydroxyindole-O-methyltransferase (HIOMT) is enzyme determining melatonin synthesis. This indoleamine exert, antioxidant, and anti-inflammatory effects. Its synthesis can be disturbed by pro-inflammatory cytokines. The obtained results noted the proliferation of EC cells and the increase of HIOMT expression in ulcerative colitis ulcerative colitis (UC). Positive correlation between the amount of EC cells and urinary 6-sulfatoxymelatonin excretion points to the increase of melatonin secretion in the colon, but its beneficial anti-inflammatory effect was insufficient. The results indicate that the supplementation of melatonin may be useful in complex treatment of UC.
Publish Date	2013-06-20 16:34
Citation	Chojnacki C, Wi?niewska-Jarosińska M, Kulig G, Majsterek I, Reiter RJ, Chojnacki J. Evaluation of enterochromaffin cells and melatonin secretion exponents in ulcerative colitis. World J Gastroenterol 2013; 19(23): 3602-3607
URL	http://www.wjgnet.com/1007-9327/full/v19/i23/3602.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i23.3602

Full Article (PDF)	WJG-19-3602.pdf
Manuscript File	941-Review.doc
Answering Reviewers	941-Answering reviewers.docx
Copyright License Agreement	941-Copyright assingnment.docx
Institutional Review Board Approval Form or Document	Ethics_Committee_Approval.pdf
Non-Native Speakers of English Editing Certificate	941-Language certificate.pdf
Peer-review Report	941-Peer review(s).pdf
Scientific Editor Work List	941-Scientific editor work list.doc