| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Causal effects of genetic birth weight and gestational age on adult esophageal diseases: Mendelian randomization study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lian-Cheng Ruan, Yang Zhang, Lang Su, Ling-Xiao Zhu, Si-Lin Wang, Qiang Guo, Bin-Gen Wan, Sheng-Yu Qiu, Sheng Hu, Yi-Ping Wei and Qiao-Ling Zheng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81860379, 81560345 |
| Key Research and Development Program of Jiangxi Province |
20223BBG71009 |
|
| Corresponding Author |
Yi-Ping Wei, MD, PhD, Chief Doctor, Professor, Surgeon, Department of Thoracic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 566 Xuefu Avenue, Honggutan District, Nanchang 330006, Jiangxi Province, China. weiyip2000@hotmail.com |
| Key Words |
Birth weight; Barrett’s esophagus; Esophageal adenocarcinoma; Gestational age; Gastroesophageal reflux disease; Preterm birth |
| Core Tip |
Our study demonstrates that low birth weight, rather than prematurity, is associated with increased risk of gastroesophageal reflux disease (GERD) and Barrett’s esophagus (BE) in adulthood, with no association found for esophageal adenocarcinoma. Furthermore, this relationship is influenced by the mediating effects of educational attainment and height. Attention to educational attainment and height during the growth process of low-birth-weight individuals is necessary to reduce the incidence of GERD and BE. |
| Publish Date |
2024-07-12 15:55 |
| Citation |
<p>Ruan LC, Zhang Y, Su L, Zhu LX, Wang SL, Guo Q, Wan BG, Qiu SY, Hu S, Wei YP, Zheng QL. Causal effects of genetic birth weight and gestational age on adult esophageal diseases: Mendelian randomization study. <i>World J Gastrointest Oncol</i> 2024; 16(7): 3055-3068</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i7/3055.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i7.3055 |
