Publication Name	World Journal of Gastroenterology
Manuscript ID	9412
Country	India

Received	2014-02-12 06:40
Peer-Review Started	2014-02-13 03:27
To Make the First Decision	2014-04-15 19:53
Return for Revision	2014-04-19 21:15
Revised	2014-05-12 15:14
Second Decision	2014-07-16 17:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-16 17:27
Articles in Press	2014-07-16 17:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-30 14:44
Publish the Manuscript Online	2014-12-18 17:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Plasma cathepsin L: A prognostic marker for pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Nidhi Singh, Prasenjit Das, Surabhi Gupta, Vikas Sachdev, Siddhartha Srivasatava, Siddhartha Datta Gupta, Ravindra Mohan Pandey, Peush Sahni, Shyam S Chauhan and Anoop Saraya
Funding Agency and Grant Number	Funding Agency Grant Number Indian Council of Medical Research, New Delhi Council of Scientific and Industrial Research, New Delhi
Corresponding Author	Anoop Saraya, Professor, Department of Gastroenterology and Human Nutrition, 3rd Floor, Teaching Block, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India. ansaraya@yahoo.com
Key Words	Cathepsin L; Pancreatic cancer; Overall median survival; Plasma
Core Tip	Cathepsin L is a lysosomal cysteine protease, which degrades extracellular matrix during cancer cell invasion. It has been shown to have prognostic value in pancreatic tumor tissue. But blood based markers can be more useful. Elevated levels of cathepsin L in plasma have been reported but no study has exhibited prognostic significance of cathepsin L levels in blood. This study for the first time reported that elevated levels of cathepsin L in plasma predict poor prognosis in pancreatic cancer and these levels decrease after surgery.
Publish Date	2014-12-18 17:08
Citation	Singh N, Das P, Gupta S, Sachdev V, Srivasatava S, Datta Gupta S, Pandey RM, Sahni P, Chauhan SS, Saraya A. Plasma cathepsin L: A prognostic marker for pancreatic cancer. World J Gastroenterol 2014; 20(46): 17532-17540
URL	http://www.wjgnet.com/1007-9327/full/v20/i46/17532.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i46.17532

Full Article (PDF)	WJG-20-17532.pdf
Full Article (Word)	WJG-20-17532.doc
Manuscript File	9412-Review.doc
Answering Reviewers	9412-Answering reviewers.pdf
Copyright License Agreement	9412-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140211023005.pdf
Non-Native Speakers of English Editing Certificate	9412-Language certificate.pdf
Peer-review Report	9412-Peer review.pdf
Scientific Misconduct Check	9412-CorssCheck.jpg
Scientific Editor Work List	9412-Scientific editor work list.pdf