Publication Name	World Journal of Gastroenterology
Manuscript ID	94122
Country	United Kingdom

Received	2024-03-11 18:28
Peer-Review Started	2024-03-11 18:28
To Make the First Decision
Return for Revision	2024-04-25 07:19
Revised	2024-05-29 20:42
Second Decision	2024-06-21 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-06-21 05:17
Articles in Press	2024-06-21 05:17
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-06-25 05:56
Typeset the Manuscript	2024-07-09 07:11
Publish the Manuscript Online	2024-07-11 08:47

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease: Clinical implications
Manuscript Source	Invited Manuscript
All Author List	Giovanna McGinty and Robert Przemioslo
ORCID	Author(s) ORCID Number Giovanna McGinty http://orcid.org/0000-0003-3953-5275
Funding Agency and Grant Number
Corresponding Author	Giovanna McGinty, MBChB, MSc, Doctor, Doctor, Department of Gastroenterology, North Bristol Trust, Southmead Hospital, Southmead Road, Bristol BS10 5NB, United Kingdom. Giovanna.sheiybani@nhs.net
Key Words	Alanine aminotransferase; Metabolic-dysfunction associated fatty liver disease; Metabolic syndrome; Fibrosis; Cirrhosis; Semaglutide
Core Tip	Alanine aminotransferase (ALT) is a surrogate marker for metabolic-dysfunction associated fatty liver disease (MAFLD) but is not specific for histological inflammation. The rationale to reduce the upper limit of normal for ALT to help identify more cases of MAFLD remains controversial. It is more important to identify patients who may display elements of the metabolic syndrome and support modifying these to maintain a lower level of ALT. This will become increasingly important as more targets for therapy are identified that may justify treating these patients early to prevent progression to fibrosis.
Publish Date	2024-07-11 08:47
Citation	<p>McGinty G, Przemioslo R. Effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease: Clinical implications. <i>World J Gastroenterol</i> 2024; 30(27): 3264-3267</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i27/3264.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i27.3264

Full Article (PDF)	WJG-30-3264-with-cover.pdf
Manuscript File	94122-Review-Filipodia.docx
Answering Reviewers	94122-answering-reviewers.pdf
Audio Core Tip	94122-audio.m4a
Conflict-of-Interest Disclosure Form	94122-conflict-of-interest-statement.pdf
Copyright License Agreement	94122-copyright-assignment.pdf
Peer-review Report	94122-peer-reviews.pdf
Scientific Misconduct Check	94122-scientific-misconduct-check.png
Scientific Editor Work List	94122-scientific-editor-work-list.pdf
CrossCheck Report	94122-crosscheck-report.pdf