| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Quantitative proteomics analysis reveals the pathogenesis of obstructed defecation syndrome caused by abnormal expression of dystrophin
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Zhe Li, Yu Xiong, Tian-Kun Wang, Yan-Yan Chen, Song-Lin Wan, Lu-Yao Li, Meng Xu, Jing-Jing Tong, Qun Qian, Cong-Qing Jiang and Wei-Cheng Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81500505 |
| Construction of Predominant Disciplines of Zhongnan Hospital of Wuhan University |
XKJS202017 |
| Medical Science and Technology Innovation Platform of Joint Foundation of Health Commission of Hubei Province, Zhongnan Hospital of Wuhan University |
PTXM2021025 |
| Hubei Provincial Natural Science Foundation |
2023AFC013 |
|
| Corresponding Author |
Wei-Cheng Liu, MD, PhD, Associate Professor, Department of Colorectal and Anal Surgery (Clinical Center for Pelvic Floor Surgery), Clinical Center of Constipation and Pelvic Floor Disease of Wuhan, Hubei Key Laboratory of Intestinal and Colorectal Diseases, Clinical Center of Intestinal and Colorectal Diseases of Hubei Province, Quality Control Center of Colorectal and Anal Surgery of Health Commission of Hubei Province, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuhan 430071, Hubei Province, China. wb000837@whu.edu.cn |
| Key Words |
Obstructed defecation syndrome; Dystrophin; Smooth muscle; Contraction; Proteomics; L-type voltage-gated calcium channel |
| Core Tip |
The long-term outcomes of numerous treatments for obstructed defecation syndrome (ODS) are now unsatisfactory. The reason is a lack of knowledge about ODS’s molecular abnormalities. Our research indicated a connection between the pathophysiology of ODS and reduced dystrophin expression. The overexpression of nucleoporin protein 153 and L-type voltage-gated calcium channel was triggered by the downregulation of dystrophin, which caused a significant flow of calcium ions into the intestinal smooth muscle cells. Overabundance of calcium ion inflow may reduce muscle contractility, which manifested as weakened rectal propulsion in ODS. |
| Publish Date |
2024-11-13 10:10 |
| Citation |
<p>Li WZ, Xiong Y, Wang TK, Chen YY, Wan SL, Li LY, Xu M, Tong JJ, Qian Q, Jiang CQ, Liu WC. Quantitative proteomics analysis reveals the pathogenesis of obstructed defecation syndrome caused by abnormal expression of dystrophin. <i>World J Gastroenterol</i> 2024; 30(45): 4817-4835</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i45/4817.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i45.4817 |
