Publication Name	World Journal of Gastroenterology
Manuscript ID	9420
Country	China

Received	2014-02-12 06:35
Peer-Review Started	2014-02-13 02:22
First Decision by Editorial Office Director
Return for Revision	2014-04-15 01:12
Revised	2014-05-09 05:49
Publication Fee Transferred
Second Decision by Editor	2014-07-30 10:00
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-07-30 10:11
Articles in Press	2014-07-30 10:38
Edit the Manuscript by Language Editor	2014-08-23 23:18
Typeset the Manuscript	2014-09-18 16:10
Publish the Manuscript Online	2014-10-07 17:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Observational Study
Article Title	Novel approach to identifying the hepatitis B virus pre-S deletions associated with hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Zhi-Mei Zhao, Yan Jin, Yu Gan, Yu Zhu, Tao-Yang Chen, Jin-Bing Wang, Yan Sun, Zhi-Gang Cao, Geng-Sun Qian and Hong Tu
Funding Agency and Grant Number	Funding Agency Grant Number Chinese state key project specialized for infectious diseases 2012ZX10002-008-002
Corresponding Author	Hong Tu, MD, PhD, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 2200-25 Xietu Road, Shanghai 200032, China. tuhong@shsci.org
Key Words	Hepatitis B virus; Pre-S deletion; Capillary gel electrophoresis; Sequence analysis; Hepatocellular carcinoma
Core Tip	Hepatitis B virus pre-S deletions are one of the risk factors associated with hepatocellular carcinoma (HCC). However, the lack of a convenient method hampers its clinical application. In this study, we develop a capillary gel electrophoresis approach that can quantitatively identify low amounts of deletions within a heterogeneous viral population. By applying this method in a case-control study, we not only confirmed previous observations that pre-S deletions increased the risk for HCC but also reported, for the first time, that only small deletions (≤ 99 bp) have a significant association with HCC, rather than large deletions.
Publish Date	2014-10-07 17:32
Citation	Zhao ZM, Jin Y, Gan Y, Zhu Y, Chen TY, Wang JB, Sun Y, Cao ZG, Qian GS, Tu H. Novel approach to identifying the hepatitis B virus pre-S deletions associated with hepatocellular carcinoma. World J Gastroenterol 2014; 20(37): 13573-13581
URL	http://www.wjgnet.com/1007-9327/full/v20/i37/13573.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i37.13573

Full Article (PDF)	WJG-20-13573.pdf
Full Article (Word)	WJG-20-13573.doc
Manuscript File	9420-Review.doc
Answering Reviewers	9420-Answering reviewers.pdf
Copyright License Agreement	9420-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140211121456.pdf
Non-Native Speakers of English Editing Certificate	9420-Language certificate.pdf
Peer-review Report	9420-Peer review.pdf
Scientific Misconduct Check	9420-CorssCheck.jpg
Scientific Editor Work List	9420-Scientific editor work list.pdf