Publication Name	World Journal of Clinical Cases
Manuscript ID	94237
Country	South Korea

Received	2024-03-14 01:37
Peer-Review Started	2024-03-14 01:37
To Make the First Decision
Return for Revision	2024-05-24 06:32
Revised	2024-05-28 14:44
Second Decision	2024-06-13 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-06-13 09:15
Articles in Press	2024-06-13 09:15
Publication Fee Transferred	2024-06-15 06:57
Edit the Manuscript by Language Editor	2024-06-20 19:40
Typeset the Manuscript	2024-06-28 08:13
Publish the Manuscript Online	2024-07-02 08:41

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Fatal intratumoral hemorrhage in a patient with hepatocellular carcinoma following successful treatment with atezolizumab/bevacizumab: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Kyeong-Hoon Park, Jeong-Ju Yoo, Sang Gyune Kim and Young Seok Kim
ORCID	Author(s) ORCID Number Jeong-Ju Yoo http://orcid.org/0000-0002-7802-0381 Sang Gyune Kim http://orcid.org/0000-0001-8694-777X
Funding Agency and Grant Number	Funding Agency Grant Number Soonchunhyang University Research Fund 20240007
Corresponding Author	Jeong-Ju Yoo, MD, PhD, Associate Professor, Department of Gastroenterology and Hepatology, Soonchunhyang University School of Medicine, 170 Jomaruro Wonmigu, Bucheonsi Gyeonggido, Bucheon 14584, South Korea. puby17@naver.com
Key Words	Adverse events; Atezolizumab; Bevacizumab; Complication; Hemorrhage; Bleeding; Hepatocellular carcinoma; Case report
Core Tip	Our study delves into the emerging therapy of atezolizumab/bevacizumab for unresectable hepatocellular carcinoma (HCC), contrasting its efficacy with traditional treatments like sorafenib. We highlight the real-world challenges of bleeding complications, particularly intratumoral bleeding, associated with bevacizumab. Presenting a rare case, we emphasize the need for proactive measures, such as baseline examinations, to mitigate bleeding risks before initiating atezolizumab/bevacizumab. Our findings underscore the critical importance of vigilant monitoring and prompt intervention to address potentially fatal complications during atezolizumab/bevacizumab therapy, contributing to the evolving understanding of HCC treatment strategies.
Publish Date	2024-07-02 08:41
Citation	<p>Park KH, Yoo JJ, Kim SG, Kim YS. Fatal intratumoral hemorrhage in a patient with hepatocellular carcinoma following successful treatment with atezolizumab/bevacizumab: A case report. <i>World J Clin Cases</i> 2024; 12(22): 5177-5183</p>
URL	https://www.wjgnet.com/2307-8960/full/v12/i22/5177.htm
DOI	https://dx.doi.org/10.12998/wjcc.v12.i22.5177

Full Article (PDF)	WJCC-12-5177-with-cover.pdf
CARE Checklist–2016	94237-CARE-Checklist-2016.pdf
Manuscript File	94237-Review-Filipodia.docx
Answering Reviewers	94237-answering-reviewers.pdf
Audio Core Tip	94237-audio.m4a
Conflict-of-Interest Disclosure Form	94237-conflict-of-interest-statement.pdf
Copyright License Agreement	94237-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	94237-foundation-statement.pdf
Signed Consent for Treatment Form(s) or Document(s)	94237-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate	94237-non-native-speakers.pdf
Peer-review Report	94237-peer-reviews.pdf
Scientific Misconduct Check	94237-scientific-misconduct-check.png
Scientific Editor Work List	94237-scientific-editor-work-list.pdf
CrossCheck Report	94237-crosscheck-report.pdf