Category |
Gastroenterology & Hepatology |
Manuscript Type |
Case Control Study |
Article Title |
Elevated miR-33a and miR-224 in steatotic chronic hepatitis C liver biopsies
|
Manuscript Source |
Unsolicited Manuscript |
All Author List |
Gabor Lendvai, Katalin Jármay, Gizella Karácsony, Tünde Halász, Ilona Kovalszky, Kornélia Baghy, Tibor Wittmann, Zsuzsa Schaff and András Kiss |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Scientific Research Fund |
OTKA K101435 |
National Scientific Research Fund |
K108548 |
National Scientific Research Fund |
105763 |
|
Corresponding Author |
Zsuzsa Schaff, MD, PhD, DSc, Professor of Pathology, 2nd Department of Pathology, Semmelweis University, Ulloi 93, 1091 Budapest, Hungary. schaff.zsuzsa@med.semmelweis-univ.hu |
Key Words |
Chronic hepatitis C; Steatosis; MicroRNA; Expression; miR-33a; miR-224 |
Core Tip |
Chronic hepatitis C (CHC) and steatosis are liver diseases that can progress into hepatocellular carcinoma. In the current study, differences were found in expression of selected microRNAs in biopsy samples of steatotic liver, CHC-infected, and steatotic CHC-infected liver, compared to control samples. Interestingly, levels of miR-224, which are increased in hepatocellular carcinoma, were elevated in both types of steatotic liver when compared with normal or CHC-infected only liver tissues, and may be an indicator of a precancerous state. |
Publish Date |
2014-11-10 19:10 |
Citation |
Lendvai G, Jármay K, Karácsony G, Halász T, Kovalszky I, Baghy K, Wittmann T, Schaff Z, Kiss A. Elevated miR-33a and miR-224 in steatotic chronic hepatitis C liver biopsies. World J Gastroenterol 2014; 20(41): 15343-15350 |
URL |
http://www.wjgnet.com/1007-9327/full/v20/i41/15343.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v20.i41.15343 |