Publication Name	World Journal of Radiology
Manuscript ID	94324
Country	China

Received	2024-03-15 16:04
Peer-Review Started	2024-03-15 16:04
To Make the First Decision
Return for Revision	2024-08-10 07:54
Revised	2024-08-14 10:01
Second Decision	2024-08-27 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-08-27 07:40
Articles in Press	2024-08-27 07:40
Publication Fee Transferred	2024-08-27 13:30
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-09-05 09:40
Publish the Manuscript Online	2024-09-27 06:35

ISSN	1949-8470 (online)
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Category	Medicine, General & Internal
Manuscript Type	Case Report
Article Title	Acquired factor XIII deficiency presenting with multiple intracranial hemorrhages and right hip hematoma: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Lei Wang, Ning Zhang, Dong-Cheng Liang, Hao-Ling Zhang and Le-Qing Lin
ORCID	Author(s) ORCID Number Le-Qing Lin http://orcid.org/0009-0008-1220-7187
Funding Agency and Grant Number	Funding Agency Grant Number Medical and Health Science Foundation of Zhejiang No. 2023KY186 Hangzhou Science and Technology Development Plan Guide Project No. 20220919Y023 Hangzhou Medical Key Discipline Construction Program No. 2021
Corresponding Author	Le-Qing Lin, PhD, Doctor, Doctor, Department of Intensive Care Medicine, Hangzhou Normal University Affiliated Hospital, No. 126 Wenzhou Road, Gongshu District, Hangzhou 310015, Zhejiang Province, China. lqxdy83641@21cn.com
Key Words	Factor XIII deficiency; Hematoma; Spontaneous; Bleeding disorder; Intracranial hemorrhages; Case report
Core Tip	Factor XIII (FXIII) deficiency is a rare yet profound coagulopathy. FXIII plays a pivotal role in hemostasis, and deficiencies in this factor can precipitate unchecked or spontaneous hemorrhaging. Immunological assays for detecting FXIII inhibitors are indispensable for diagnosing acquired FXIII deficiency; however, the availability of suitable testing facilities is limited, resulting in prolonged turnaround times for these assays. In this case study, a 53-year-old male devoid of significant medical history presented with recurrent intracranial hemorrhages and a hematoma in the right hip. Subsequent genetic analysis revealed a homozygous mutation in the ACE gene, confirming the diagnosis of acquired FXIII deficiency. This case underscores the imperative of contemplating acquired coagulopathies in individuals experiencing unexplained and recurrent hemorrhagic episodes. Furthermore, it underscores the value of thorough genetic analysis in uncovering uncommon coagulation anomalies, which can substantially influence patient care and prognosis. Subsequent investigations could delve into elucidating the pathophysiological mechanisms underpinning mutations in the ACE gene and their interplay with coagulation pathways. Acquired FXIII deficiency, albeit uncommon, warrants consideration in individuals presenting with inexplicable hemorrhagic episodes. Genetic testing emerges as pivotal in the diagnosis and therapeutic approach to such instances.
Publish Date	2024-09-27 06:35
Citation	<p>Wang L, Zhang N, Liang DC, Zhang HL, Lin LQ. Acquired factor XIII deficiency presenting with multiple intracranial hemorrhages and right hip hematoma: A case report. <i>World J Radiol</i> 2024; 16(9): 439-445</p>
URL	https://www.wjgnet.com/1949-8470/full/v16/i9/439.htm
DOI	https://dx.doi.org/10.4329/wjr.v16.i9.439

Full Article (PDF)	WJR-16-439-with-cover.pdf
CARE Checklist–2016	94324-CARE-Checklist-2016.pdf
Manuscript File	94324_Auto_Edited_074745.docx
Answering Reviewers	94324-answering-reviewers.pdf
Audio Core Tip	94324-audio.mp3
Conflict-of-Interest Disclosure Form	94324-conflict-of-interest-statement.pdf
Copyright License Agreement	94324-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	94324-foundation-statement.pdf
Signed Consent for Treatment Form(s) or Document(s)	94324-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate	94324-non-native-speakers.pdf
Peer-review Report	94324-peer-reviews.pdf
Scientific Misconduct Check	94324-scientific-misconduct-check.png
Scientific Editor Work List	94324-scientific-editor-work-list.pdf
CrossCheck Report	94324-crosscheck-report.png
CrossCheck Report	94324-crosscheck-report.pdf