Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	9433
Country	Japan

Received	2014-02-19 11:08
Peer-Review Started	2014-02-20 21:10
First Decision by Editorial Office Director
Return for Revision	2014-04-10 22:58
Revised	2014-05-01 18:17
Publication Fee Transferred
Second Decision by Editor	2014-09-10 13:27
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-09-10 13:48
Articles in Press	2014-09-10 13:48
Edit the Manuscript by Language Editor	2014-09-15 19:21
Typeset the Manuscript	2014-10-28 20:07
Publish the Manuscript Online	2014-11-19 10:25

ISSN	2150-5330 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Health Care Sciences & Services
Manuscript Type	Minireviews
Article Title	Genetic and environmental determinants of risk for cholangiocarcinoma in Thailand
Manuscript Source	Invited Manuscript
All Author List	Masanao Miwa, Satoshi Honjo, Gyokukou You, Masakazu Tanaka, Kazuhiko Uchida, Petcharin Srivatanakul, Thiravud Khuhaprema, Watcharin Loilome, Anchalee Techasen, Chaisiri Wongkham, Temduang Limpaiboon, Puangrat Yongvanit and Sopit Wongkham
Funding Agency and Grant Number	Funding Agency Grant Number Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology Japan
Corresponding Author	Masanao Miwa, MD, PhD, Nagahama Institute of Bio-Science and Technology, Nagahama, Shiga 526-0829, Japan. m_miwa@nagahama-i-bio.ac.jp
Key Words	Alcohol drinking; Cholangiocarcinoma; DNA polymorphism; Glutathione S transferase; 8-oxoguanine glycosylase 1; Liver fluke; Opisthorchis viverrini; Thailand
Core Tip	Cholangiocarcinoma (CCA) is an intractable cancer due to the difficulty of diagnosis in its early stage. The incidence of CCA in the northeast of Thailand is the highest in the world. It is of the utmost importance to analyze the risk factors and the mechanism to prevent the disease and to also detect the disease in its early stage to save patients’ lives. We analyzed the genetic and environmental determinants of risks for CCA and discussed this with the findings already published by other researchers. It is of the utmost importance to develop a non-invasive, specific and sensitive method to detect CCA.
Publish Date	2014-11-19 10:25
Citation	Miwa M, Honjo S, You G, Tanaka M, Uchida K, Srivatanakul P, Khuhaprema T, Loilome W, Techasen A, Wongkham C, Limpaiboon T, Yongvanit P, Wongkham S. Genetic and environmental determinants of risk for cholangiocarcinoma in Thailand. World J Gastrointest Pathophysiol 2014; 5(4): 570-578
URL	http://www.wjgnet.com/2150-5330/full/v5/i4/570.htm
DOI	http://dx.doi.org/10.4291/wjgp.v5.i4.570

Full Article (PDF)	WJGP-5-570.pdf
Full Article (Word)	WJGP-5-570.doc
Manuscript File	9433-Review.docx
Answering Reviewers	9433-Answering reviewers.pdf
Copyright License Agreement	9433-Copyright assignment.pdf
Peer-review Report	9433-Peer review(s).pdf
Scientific Misconduct Check	9433-CrossCheck.jpg
Scientific Editor Work List	9433-Scientific editor work list.pdf