Publication Name	World Journal of Diabetes
Manuscript ID	94360
Country	China

Received	2024-03-17 03:00
Peer-Review Started	2024-03-17 03:00
To Make the First Decision
Return for Revision	2024-08-15 05:07
Revised	2024-08-28 14:57
Second Decision	2024-09-24 08:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-10 06:55
Articles in Press	2024-10-10 06:55
Publication Fee Transferred	2024-10-12 08:31
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-16 05:36
Publish the Manuscript Online	2024-11-18 03:30

ISSN	1948-9358 (online)
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Category	Dermatology
Manuscript Type	Basic Study
Article Title	Shikonin protects mitochondria through the NFAT5/AMPK pathway for the treatment of diabetic wounds
Manuscript Source	Unsolicited Manuscript
All Author List	Lu-Sha Cen, Yi Cao, Yi-Mai Zhou, Jing Guo and Jing-Wen Xue
ORCID	Author(s) ORCID Number Lu-Sha Cen http://orcid.org/0000-0001-7223-340X
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82104862 Zhejiang Provincial Natural Science Foundation of China LTY22E030003 Scientific Research Project Fundation of Zhejiang Chinese Medical University 2023FSYYZZ01
Corresponding Author	Lu-Sha Cen, PhD, Attending Doctor, Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), No. 54 Youdian Road, Hangzhou 310006, Zhejiang Province, China. cenlusa2@sina.com
Key Words	Shikonin; Diabetic wounds; NFAT5; Mitochondrial function; AMPK; Wound healing
Core Tip	NFAT5 is a potential therapeutic target for diabetes. Shikonin is a natural remedy that is ideal for treating diabetic wounds. In this study we confirmed that shikonin suppresses the pathological expression of NFAT5, thereby protecting mitochondrial function, inhibiting cellular inflammation, and reducing reactive oxygen species production. Furthermore, we found that shikonin protects mitochondria through the NFAT5/AMPK pathway. Our research provides novel insights into the contribution of shikonin to the treatment of diabetes.
Publish Date	2024-11-18 03:30
Citation	<p>Cen LS, Cao Y, Zhou YM, Guo J, Xue JW. Shikonin protects mitochondria through the NFAT5/AMPK pathway for the treatment of diabetic wounds. <i>World J Diabetes</i> 2024; 15(12): 2338-2352</p>
URL	https://www.wjgnet.com/1948-9358/full/v15/i12/2338.htm
DOI	https://dx.doi.org/10.4239/wjd.v15.i12.2338

Full Article (PDF)	WJD-15-2338-with-cover.pdf
The ARRIVE Guidelines	94360-The-ARRIVE-Guidelines.pdf
Manuscript File	94360_Auto_Edited_074525.docx
Answering Reviewers	94360-answering-reviewers.pdf
Audio Core Tip	94360-audio.m4a
Biostatistics Review Certificate	94360-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	94360-conflict-of-interest-statement.pdf
Copyright License Agreement	94360-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	94360-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	94360-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	94360-non-native-speakers.pdf
Peer-review Report	94360-peer-reviews.pdf
Journal Editor-in-Chief Review Report	94360-journal-editor-in-chief.pdf
Scientific Misconduct Check	94360-scientific-misconduct-check.png
Scientific Editor Work List	94360-scientific-editor-work-list.pdf
CrossCheck Report	94360-crosscheck-report.pdf