Publication Name	World Journal of Stem Cells
Manuscript ID	94446
Country	China

Received	2024-03-19 06:36
Peer-Review Started	2024-03-19 06:37
To Make the First Decision
Return for Revision	2024-06-20 05:14
Revised	2024-07-04 01:21
Second Decision	2024-07-29 05:44
Accepted by Journal Editor-in-Chief	2024-08-04 06:23
Accepted by Executive Editor-in-Chief	2024-08-15 09:49
Articles in Press	2024-08-15 09:49
Publication Fee Transferred	2024-08-19 13:38
Edit the Manuscript by Language Editor	2024-08-22 00:29
Typeset the Manuscript	2024-08-23 02:03
Publish the Manuscript Online	2024-08-26 05:32

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Respiratory System
Manuscript Type	Basic Study
Article Title	Microvesicles derived from mesenchymal stem cells inhibit acute respiratory distress syndrome-related pulmonary fibrosis in mouse partly through hepatocyte growth factor
Manuscript Source	Unsolicited Manuscript
All Author List	Qi-Hong Chen, Ying Zhang, Xue Gu, Peng-Lei Yang, Jun Yuan, Li-Na Yu and Jian-Mei Chen
ORCID	Author(s) ORCID Number Jian-Mei Chen http://orcid.org/0000-0003-0178-4954
Funding Agency and Grant Number	Funding Agency Grant Number Research Project of Jiangsu Provincial Health Commission Z2022008 Research Project of Yangzhou Health Commission 2023-2-27
Corresponding Author	Jian-Mei Chen, PhD, Researcher, Institute of Translational Medicine, Yangzhou University, No. 136 Jiangyang Middle Road, Hanjiang District, Yangzhou 225000, Jiangsu Province, China. 18051063567@163.com
Key Words	Microvesicles derived from mesenchymal stem cells; Acute respiratory distress syndrome; Pulmonary fibrosis; Hepatocyte growth factor; Mesenchymal stromal cells
Core Tip	Pulmonary fibrosis is strongly associated with poor outcomes in acute respiratory distress syndrome (ARDS) patients. Currently, there are no effective measures for treating pulmonary fibrosis. Microvesicles derived from mesenchymal stromal cells (MSC-MVs) have anti-pulmonary fibrosis effects; however, their specific effects and mechanisms in ARDS-related pulmonary fibrosis have not been fully established. This study revealed that MSC-MVs inhibited ARDS-related pulmonary fibrosis and fibrosis-related factors partly through hepatocyte growth factor, improved lung compliance and ventilation functions, and increased oxygenation indices. This study provides a new direction for the treatment of ARDS-related pulmonary fibrosis.
Publish Date	2024-08-26 05:32
Citation	<p>Chen QH, Zhang Y, Gu X, Yang PL, Yuan J, Yu LN, Chen JM. Microvesicles derived from mesenchymal stem cells inhibit acute respiratory distress syndrome-related pulmonary fibrosis in mouse partly through hepatocyte growth factor. <i>World J Stem Cells</i> 2024; 16(8): 811-823</p>
URL	https://www.wjgnet.com/1948-0210/full/v16/i8/811.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i8.811

Full Article (PDF)	WJSC-16-811-with-cover.pdf
The ARRIVE Guidelines	94446-The-ARRIVE-Guidelines.pdf
Manuscript File	94446_Auto_Edited_035804.docx
Answering Reviewers	94446-answering-reviewers.pdf
Audio Core Tip	94446-audio.mp3
Biostatistics Review Certificate	94446-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	94446-conflict-of-interest-statement.pdf
Copyright License Agreement	94446-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	94446-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	94446-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	94446-non-native-speakers.pdf
Peer-review Report	94446-peer-reviews.pdf
Journal Editor-in-Chief Review Report	94446-journal-editor-in-chief.pdf
Scientific Misconduct Check	94446-scientific-misconduct-check.png
Scientific Editor Work List	94446-scientific-editor-work-list.pdf
CrossCheck Report	94446-crosscheck-report.pdf