Publication Name	World Journal of Gastroenterology
Manuscript ID	9451
Country	United States

Received	2014-02-12 23:45
Peer-Review Started	2014-02-13 08:29
To Make the First Decision	2014-04-02 19:44
Return for Revision	2014-04-12 06:25
Revised
Second Decision	2014-05-19 10:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-19 11:31
Articles in Press	2014-05-23 09:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-30 11:50
Publish the Manuscript Online	2014-09-18 19:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	TLR4 signaling and the inhibition of liver hepcidin expression by alcohol
Manuscript Source	Invited Manuscript
All Author List	Emily Zmijewski, Sizhao Lu and Duygu Dee Harrison-Findik
Funding Agency and Grant Number	Funding Agency Grant Number NIH R01AA017738 (to Harrison-Findik DD) University of Nebraska Medical Center Undergraduate Scholarship to Lu S
Corresponding Author	Duygu Dee Harrison-Findik, PhD, Department of Internal Medicine, University of Nebraska Medical Center, 95820 UNMC, DRC I, Omaha, NE 68198-5820, United States. dharrisonfindik@unmc.edu
Key Words	Iron; Small heterodimer partner protein; Nuclear factor-B; Alcoholic liver disease; Inflammation
Core Tip	Chronic alcohol intake induces inflammation and also alters iron homeostasis by inhibiting the expression of hepcidin in the liver. Besides being the key iron-regulatory hormone, hepcidin also acts as an acute phase protein, and is induced by endotoxin and inflammation. The mechanisms by which chronic alcohol consumption can lead to the suppression of hepcidin expression despite the presence of inflammatory processes in the liver are unknown. This study investigates these mechanisms by using wildtype and toll-like receptor 4 mutant mice, and chronic alcohol administration as a model.
Publish Date	2014-09-18 19:50
Citation	Zmijewski E, Lu S, Harrison-Findik DD. TLR4 signaling and the inhibition of liver hepcidin expression by alcohol. World J Gastroenterol 2014; 20(34): 12161-12170
URL	http://www.wjgnet.com/1007-9327/full/v20/i34/12161.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i34.12161

Full Article (PDF)	WJG-20-12161.pdf
Full Article (Word)	WJG-20-12161.doc
Manuscript File	9451-Review.docx
Answering Reviewers	9451-Answering reviewer.pdf
Copyright License Agreement	9451-Copyright assignment.pdf
Peer-review Report	9451-Peer reviews.pdf
Scientific Editor Work List	9451-Scientific editor work list.pdf