Publication Name	World Journal of Methodology
Manuscript ID	94514
Country	India

Received	2024-03-19 16:30
Peer-Review Started	2024-03-19 16:30
To Make the First Decision
Return for Revision	2024-08-15 06:37
Revised	2024-09-23 18:55
Second Decision	2024-10-18 01:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-20 09:20
Articles in Press	2024-10-20 09:20
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-11-07 03:14
Typeset the Manuscript	2024-11-19 07:42
Publish the Manuscript Online	2024-11-27 10:57

ISSN	2222-0682 (online)
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Category	Dentistry, Oral Surgery & Medicine
Manuscript Type	Retrospective Study
Article Title	Immunohistochemical expression of matrix metalloproteinase-9 and 13 in oral squamous cell carcinoma and their role in predicting lymph node metastasis
Manuscript Source	Invited Manuscript
All Author List	Bhari Sharanesha Manjunatha, Keshav T Handge, Vandana Sandeep Shah, Yasser Eid Al-Thobaiti and Deepak Gowda Sadashivappa Pateel
ORCID	Author(s) ORCID Number Bhari Sharanesha Manjunatha http://orcid.org/0000-0002-4415-2538 Vandana Sandeep Shah http://orcid.org/0000-0001-9049-3942 Yasser Eid Al-Thobaiti http://orcid.org/0000-0002-6268-2719 Deepak Gowda Sadashivappa Pateel http://orcid.org/0000-0003-0769-8125
Funding Agency and Grant Number
Corresponding Author	Bhari Sharanesha Manjunatha, Associate Professor, Dept of Basic Oral Medicine and Allied Dental Sciences, Taif University, At`Taif 26571, Makkah, Saudi Arabia. drmanju26@hotmail.com
Key Words	Matrix metalloproteinases; Squamous cell carcinoma of the oral cavity; Tumor staging; Immunohistochemistry; Invasion neoplasm; Metastasis lymphatic; Staging TNM; Invasion neoplasm
Core Tip	The most prevalent type of cancer in head and neck cancer is oral cavity squamous cell carcinoma (OCSCC). The major cause of the poor prognosis is extensive local invasion that spreads to the lymph nodes. Degradation of the matrix and spread of cancer cells are major characteristics of malignant tumors. Hence, in the present study, matrix metallo protein (MMP)-9 and 13 were used to understand and interpret the invasion and metastasis in OSCC. Most of the cases showed various staining intensity for MMP-9 and MMP-13. There was no significance found for tumor size, however a significant relationship (P = 0.000) was observed with metastasis.
Publish Date	2024-11-27 10:57
Citation	<p>Manjunatha BS, Handge KT, Shah VS, Al-Thobaiti YE, Pateel DGS. Immunohistochemical expression of matrix metalloproteinase-9 and 13 in oral squamous cell carcinoma and their role in predicting lymph node metastasis. <i>World J Methodol</i> 2025; 15(2): 94514</p>
URL	https://www.wjgnet.com/2222-0682/full/v15/i2/94514.htm
DOI	https://dx.doi.org/10.5662/wjm.v15.i2.94514

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