Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	9454
Country	Japan

Received	2014-02-12 23:40
Peer-Review Started	2014-02-13 09:44
First Decision by Editorial Office Director
Return for Revision	2014-03-11 21:25
Revised	2014-04-08 19:25
Publication Fee Transferred
Second Decision by Editor	2014-06-27 17:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-06-27 17:52
Articles in Press	2014-06-27 18:12
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-09 17:22
Publish the Manuscript Online	2014-08-14 16:58

ISSN	1948-5190 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Lymphoepithelioma-like esophageal carcinoma with macroscopic reduction
Manuscript Source	Unsolicited Manuscript
All Author List	Masaya Uesato, Tuguaki Kono, Tooru Shiratori, Yasunori Akutsu, Isamu Hoshino, Kentarou Murakami, Daisuke Horibe, Tetsurou Maruyama, Yoshihide Semba, Ryuma Urahama, Yukiko Ogura, Takashi Oide, Toru Tanizawa and Hisahiro Matsubara
Funding Agency and Grant Number
Corresponding Author	Masaya Uesato, MD, Department of Frontier Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8670, Japan. uesato@faculty.chiba-u.jp
Key Words	Esophageal cancer; Lymphoepithelioma-like carcinoma; Lymphoid stroma; Tumor-infiltrating lymphocyte; Cytotoxic T lymphocyte; Reduction
Core Tip	The first case of esophageal lymphoepithelioma-like carcinoma showing macroscopic reduction is reported. In only 2 mo, the appearance of the esophageal tumor changed from a protruding lesion to a flat scar-like entity. After esophagectomy, one lymph node was diagnosed with metastasis. Prominent infiltration of T lymphoid cells that stained positive for CD8 was observed around the carcinoma cells. Strong expression of human leukocyte antigen-DR was evident in the cell membrane. The immune responses against the main tumor and the denatured carcinoma cells in the metastatic lymph node developed at the same time. Therefore, systemic immune responses against the carcinoma might have been occurring.
Publish Date	2014-08-14 16:58
Citation	Uesato M, Kono T, Shiratori T, Akutsu Y, Hoshino I, Murakami K, Horibe D, Maruyama T, Semba Y, Urahama R, Ogura Y, Oide T, Tanizawa T, Matsubara H. Lymphoepithelioma-like esophageal carcinoma with macroscopic reduction. World J Gastrointest Endosc 2014; 6(8): 385-389
URL	http://www.wjgnet.com/1948-5190/full/v6/i8/385.htm
DOI	http://dx.doi.org/10.4253/wjge.v6.i8.385

Full Article (PDF)	WJGE-6-385.pdf
Manuscript File	9454-Review.doc
Answering Reviewers	9454-Answering reviewers.pdf
Copyright License Agreement	9454-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	9454-Language certificate.pdf
Peer-review Report	9454-Peer review(s).pdf
Scientific Misconduct Check	9454-CrossCheck.jpg
Scientific Editor Work List	9454-Scientific editor work list.pdf