| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Helicobacter pylori infection alters the gastric microbiota structure and biological functions in patients with gastric ulcers
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ling-Xiao Jin, Yu-Peng Fang, Chen-Mei Xia, Teng-Wei Cai, Qian-Qian Li, Yu-Yin Wang, Hai-Fan Yan and Xia Chen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Wenling Science and Technology Program, China |
2020S0180101 |
| Science and Technology Program of Traditional Chinese Medicine in Zhejiang Province, China |
2023ZL784 |
|
| Corresponding Author |
Xia Chen, MM, Chief Physician, Department of Gastroenterology, Wenling Hospital of Wenzhou Medical University (The First People's Hospital of Wenling), No.333, Chuan'an South Road, Chengxi Street, Wenling 317500, Zhejiang Province, China. werla@sina.com |
| Key Words |
Helicobacter pylori; Gastric ulcer; Duodenal ulcer; Metagenomic sequence; Transfer RNA queuosine-modification; Menaquinones |
| Core Tip |
In this study, we explored the influence and mechanism of action of Helicobacter pylori (H. pylori) on the development of gastric ulcer and duodenal ulcer, which is currently inconclusive. Metagenomic sequencing was performed on mucosa from H. pylori-infected patients with gastric ulcer or duodenal ulcer and healthy individuals. Mucosal flora structure, differentially functional genes, and metabolic pathways have been analyzed to explore the role that H. pylori plays in the development of gastric ulcer and duodenal ulcer. Ultimately, two key metabolic pathways and related genes contribute from H. pylori were identified. |
| Publish Date |
2024-06-25 10:41 |
| Citation |
<p>Jin LX, Fang YP, Xia CM, Cai TW, Li QQ, Wang YY, Yan HF, Chen X. Helicobacter pylori infection alters the gastric microbiota structure and biological functions in patients with gastric ulcers. <i>World J Gastroenterol</i> 2024; 30(24): 3076-3085</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i24/3076.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i24.3076 |
