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Articles Published Processes
9/26/2024 8:51:02 AM | Browse: 156 | Download: 642
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Received |
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2024-03-25 05:27 |
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Peer-Review Started |
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2024-03-25 05:27 |
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First Decision by Editorial Office Director |
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2024-08-15 21:07 |
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Return for Revision |
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2024-08-15 21:07 |
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Revised |
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2024-08-16 06:39 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-08-26 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-08-26 07:29 |
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Articles in Press |
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2024-08-26 07:29 |
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Edit the Manuscript by Language Editor |
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2024-08-30 06:04 |
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Typeset the Manuscript |
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2024-09-05 09:51 |
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Publish the Manuscript Online |
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2024-09-26 08:51 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Interleukin-35: A key player managing pre-diabetes and chronic inflammatory type 1 autoimmune diabetes
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ratul CHakraborty, Ashis Kumar Mukherjee and Asis Bala |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Asis Bala, PhD, Professor, Pharmacology and Drug Discovery Research Laboratory, Division of Life Sciences, Institute of Advanced Study in Science and Technology, Vigyan Path, Guwahati 781035, Assam, India. asisbala@iasst.gov.in |
| Key Words |
Interleukin-35; Chronic inflammatory type 1; Autoimmune diabetes; Pancreatic inflammation; Gene disease association |
| Core Tip |
Studies suggest interleukin-35 (IL-35) protects against prediabetes and autoimmune diabetes by regulating macrophage polarization, T-cell-related cytokines, and regulatory B cells. The development and progression of autoimmune diabetes or type 1 diabetes (T1D) can be influenced by various cytokines produced by both immune and pancreatic cells. Some cytokines, such as IL-10, transforming growth factor beta (TGF-β), IL-5, IL-4, IL-2, IL-15, IL-33, and IL-35, can stimulate regulatory cells in the immune system, releasing anti-inflammatory cytokines such as IL-10. Regulatory dendritic cells release IL-7, which is particularly important for maintaining Tregs. In T1D, Tregs selectively express IL-7Rα. Inhibition of TGF-β and activation of Interferon-gamma can increase the expression of TC, Th1, and Th17 cells, while TGF-β can stimulate Runx1 expression to convert Th1 cells into Th17 cells. |
| Publish Date |
2024-09-26 08:51 |
| Citation |
CHakraborty R, Mukherjee AK, Bala A. Interleukin-35: A key player managing pre-diabetes and chronic inflammatory type 1 autoimmune diabetes. World J Diabetes 2024; 15(10): 2147-2151 |
| URL |
https://www.wjgnet.com/1948-9358/full/v15/i10/2147.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v15.i10.2147 |
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