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Articles Published Processes
8/12/2024 8:42:28 AM | Browse: 53 | Download: 184
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Received |
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2024-04-03 14:21 |
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Peer-Review Started |
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2024-04-03 14:21 |
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To Make the First Decision |
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Return for Revision |
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2024-04-29 08:32 |
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Revised |
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2024-05-29 14:34 |
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Second Decision |
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2024-07-02 02:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-07-02 06:45 |
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Articles in Press |
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2024-07-02 06:45 |
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Publication Fee Transferred |
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2024-07-10 07:00 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-08-05 11:19 |
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Publish the Manuscript Online |
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2024-08-12 08:42 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Basic Study |
| Article Title |
Botulinum toxin type A-targeted SPP1 contributes to neuropathic pain by the activation of microglia pyroptosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Ping Chen, Xiao-Die Gui, Wen-Di Tian, Hou-Ming Kan, Jin-Zhao Huang and Fu-Hai Ji |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Fu-Hai Ji, MD, Professor, Department of Anesthesiology, The First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou 215006, Jiangsu Province, China. jifuhai@suda.edu.cn |
| Key Words |
Botulinum toxin A; SPP1; Microglia; Pyroptosis; Neuropathic pain |
| Core Tip |
Neuropathic pain (NP) arises from structural lesions that induce functional abnormalities in the central and peripheral nervous systems. This condition plagues approximately 10% of the population. In this study, we found that microglial pyroptosis was closely correlated with NP progression and that botulinum toxin type A (BTX-A) treatment notably alleviated this. Our mechanistic study identified that SPP1 may be positively correlated with microglial pyroptosis and inflammation during NP and that it is targeted by BTX-A. These findings provide novel evidence for the application of BTX-A in the treatment of NP. |
| Publish Date |
2024-08-12 08:42 |
| Citation |
<p>Chen LP, Gui XD, Tian WD, Kan HM, Huang JZ, Ji FH. Botulinum toxin type A-targeted SPP1 contributes to neuropathic pain by the activation of microglia pyroptosis. <i>World J Psychiatry</i> 2024; 14(8): 1254-1266</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v14/i8/1254.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v14.i8.1254 |
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