Publication Name	World Journal of Gastroenterology
Manuscript ID	94860
Country	China

Received	2024-03-27 03:09
Peer-Review Started	2024-03-27 03:09
To Make the First Decision
Return for Revision	2024-08-13 22:27
Revised	2024-08-26 04:25
Second Decision	2024-10-14 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-14 07:08
Articles in Press	2024-10-14 07:08
Publication Fee Transferred	2024-10-17 23:14
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-23 08:32
Publish the Manuscript Online	2024-10-31 10:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Transfection of 12/15-lipoxygenase effectively alleviates inflammatory responses during experimental acute pancreatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Wei Sun, Yong-Yu Bai, Zhen-Liu Qin, Ri-Zhao Li, Tinotenda Blessing Madzikatire, Percy David Papa Akuetteh, Qiang Li, Hong-Ru Kong and Yue-Peng Jin
ORCID	Author(s) ORCID Number Yong-Yu Bai http://orcid.org/0000-0001-7489-1123 Ri-Zhao Li http://orcid.org/0000-0002-5272-1120 Yue-Peng Jin http://orcid.org/0000-0002-6530-6815
Funding Agency and Grant Number	Funding Agency Grant Number National Health Commission Research Fund WKJ-ZJ-2342 National Natural Science Foundation of China 81900583 Science and Technology Plan Project of Wenzhou Y20180103
Corresponding Author	Yue-Peng Jin, PhD, Associate Chief Physician, National Key Clinical Specialty (General Surgery), The First Affiliated Hospital Of Wenzhou Medical University, Nanbaixiang Street, Wenzhou 325000, Zhejiang Province, China. quiet1981@163.com
Key Words	Acute pancreatitis; Cerulein; 12/15-lipoxygenase; Apoptosis; Autophagy
Core Tip	Our in vivo data demonstrated for the first time that arachidonate 15-lipoxygenase (Alox15) transfection attenuated cerulein-induced acute pancreatitis (AP) in a murine model, highlighting its regulatory role in inflammation, apoptosis, and autophagy. These findings suggested that Alox15 may serve as a potential therapeutic target for the treatment of AP by modulating the key cellular processes involved in the pathology of this disease.
Publish Date	2024-10-31 10:39
Citation	<p>Sun HW, Bai YY, Qin ZL, Li RZ, Madzikatire TB, Akuetteh PDP, Li Q, Kong HR, Jin YP. Transfection of 12/15-lipoxygenase effectively alleviates inflammatory responses during experimental acute pancreatitis. <i>World J Gastroenterol</i> 2024; 30(42): 4544-4556</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i42/4544.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i42.4544

Full Article (PDF)	WJG-30-4544-with-cover.pdf
The ARRIVE Guidelines	94860-The-ARRIVE-Guidelines.pdf
Manuscript File	94860_Auto_Edited_002823.docx
Answering Reviewers	94860-answering-reviewers.pdf
Audio Core Tip	94860-audio.mp3
Biostatistics Review Certificate	94860-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	94860-conflict-of-interest-statement.pdf
Copyright License Agreement	94860-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	94860-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	94860-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	94860-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	94860-non-native-speakers.pdf
Peer-review Report	94860-peer-reviews.pdf
Scientific Misconduct Check	94860-scientific-misconduct-check.png
Scientific Editor Work List	94860-scientific-editor-work-list.pdf
CrossCheck Report	94860-crosscheck-report.pdf