| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Non-invasively differentiate non-alcoholic steatohepatitis by visualizing hepatic integrin αvβ3 expression with a targeted molecular imaging modality
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Quan Huang, Ling Wu, Chun-Yan Xue, Chen-Yi Rao, Qing-Qing Fang, Ying Chen, Cao Xie, Sheng-Xiang Rao, Shi-Yao Chen and Feng Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81670513 |
| Young Scientists Fund of the National Natural Science Foundation of China |
No. 81900511 |
|
| Corresponding Author |
Feng Li, MD, Associate Chief Physician, Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai 200032, China. li.feng2@zs-hospital.sh.cn |
| Key Words |
Non-alcoholic steatohepatitis; Cyclic peptides; Magnetic resonance imaging; Non-invasive diagnosis; Hepatic integrin αvβ3 |
| Core Tip |
Early identification of non-alcoholic steatohepatitis (NASH) patients and accurate assessment of non-alcoholic fatty liver disease severity are crucial for improving patient outcomes. Currently, no non-invasive method can replace liver biopsy to accurately discern NASH. Hepatic integrin αvβ3 expression significantly increased as simple fatty liver progressed to steatohepatitis. Inflammatory-injured hepatocytes, which might be the primary cells expressing integrin αvβ3 in steatohepatitis, were identified on the basis of steatosis. Utilizing gadolinium-labeled cyclic arginine-glycine-aspartic acid peptide as a contrast agent, steatohepatitis was successfully differentiated by visualizing hepatic integrin αvβ3 expression using an magnetic resonance imaging modality. |
| Publish Date |
2024-11-06 09:51 |
| Citation |
<p>Huang XQ, Wu L, Xue CY, Rao CY, Fang QQ, Chen Y, Xie C, Rao SX, Chen SY, Li F. Non-invasively differentiate non-alcoholic steatohepatitis by visualizing hepatic integrin αvβ3 expression with a targeted molecular imaging modality. <i>World J Hepatol</i> 2024; 16(11): 1290-1305</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i11/1290.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i11.1290 |
