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7/1/2024 6:03:24 AM | Browse: 174 | Download: 299
Publication Name World Journal of Clinical Cases
Manuscript ID 94952
Country China
Received
2024-04-07 13:21
Peer-Review Started
2024-04-07 13:21
To Make the First Decision
Return for Revision
2024-04-30 09:08
Revised
2024-05-23 14:47
Second Decision
2024-06-03 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2024-06-03 10:00
Articles in Press
2024-06-03 10:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
2024-06-16 17:56
Typeset the Manuscript
2024-06-27 08:29
Publish the Manuscript Online
2024-07-01 06:03
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Case Report
Article Title Advanced lung adenocarcinoma with EGFR 19-del mutation transformed into squamous cell carcinoma after EGFR-tyrosine kinase inhibitors treatment: A case report
Manuscript Source Unsolicited Manuscript
All Author List Xing-Zu Ji, Zhong-Da Liu, Yi-Ping Ye, Quan Li, Xiao-Jing Liu, Min-Hua Zhou and Yi Jin
ORCID
Author(s) ORCID Number
Yi Jin http://orcid.org/0009-0009-6981-935X
Funding Agency and Grant Number
Corresponding Author Yi Jin, BMed, Attending Doctor, Department of Emergency Medicine, Lishui People's Hospital, No. 15 Mass Street, Liandu District, Lishui 323000, Zhejiang Province, China. 15990421805@163.com
Key Words Lung adenocarcinoma; Squamous cell carcinoma; Pathological histological transformation; Epidermal growth factor receptor tyrosine kinase inhibitor; Drug resistance; Case report
Core Tip Patients inevitably encounter drug resistance issues after receiving epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment; EGFR-TKI resistance can be divided into primary and acquired. Pathological transformation is one of the mechanisms of acquired resistance in EGFR-TKIs, with squamous cell carcinoma transformation being relatively rare. This study provides detailed insights into a 67-year-old female patient with EGFR 19-del mutation in advanced lung adenocarcinoma who developed drug resistance after treatment with EGFR-TKIs. Our results provide a detailed analysis of the patient’s diagnosis and treatment process, alongside a review of literature on squamous cell carcinoma transformation after EGFR-TKI treatment for lung adenocarcinoma.
Publish Date 2024-07-01 06:03
Citation <p>Ji XZ, Liu ZD, Ye YP, Li Q, Liu XJ, Zhou MH, Jin Y. Advanced lung adenocarcinoma with EGFR 19-del mutation transformed into squamous cell carcinoma after EGFR-tyrosine kinase inhibitors treatment: A case report. <i>World J Clin Cases</i> 2024; 12(20): 4405-4411</p>
URL https://www.wjgnet.com/2307-8960/full/v12/i20/4405.htm
DOI https://dx.doi.org/10.12998/wjcc.v12.i20.4405
Full Article (PDF) WJCC-12-4405-with-cover.pdf
CARE Checklist–2016 94952-CARE-Checklist-2016.pdf
Manuscript File 94952-Review-FilipodiaCL.docx
Answering Reviewers 94952-answering-reviewers.pdf
Audio Core Tip 94952-audio.mp3
Conflict-of-Interest Disclosure Form 94952-conflict-of-interest-statement.pdf
Copyright License Agreement 94952-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s) 94952-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate 94952-non-native-speakers.pdf
Peer-review Report 94952-peer-reviews.pdf
Scientific Misconduct Check 94952-scientific-misconduct-check.png
Scientific Editor Work List 94952-scientific-editor-work-list.pdf
CrossCheck Report 94952-crosscheck-report.pdf