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Articles Published Processes
12/18/2014 5:08:00 PM | Browse: 1533 | Download: 1985
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Received |
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2014-02-14 11:40 |
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Peer-Review Started |
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2014-02-14 14:14 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-04-14 08:12 |
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Revised |
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2014-04-24 00:58 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-07-25 09:25 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-07-25 09:49 |
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Articles in Press |
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2014-07-25 09:55 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-11-30 16:46 |
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Publish the Manuscript Online |
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2014-12-18 17:08 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Anti-tumour necrosis factor agent and liver injury: Literature review, recommendations for management
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Roberta Elisa Rossi, Ioanna Parisi, Edward John Despott, Andrew Kenneth Burroughs, James O'Beirne, Dario Conte, Mark Ian Hamilton and Charles Daniel Murray |
| Funding Agency and Grant Number |
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| Corresponding Author |
Roberta Elisa Rossi, MD, Centre for Gastroenterology, Royal Free Hospital, Pond Street, London NW3 2QG, United Kingdom. robertaelisa.rossi@gmail.com |
| Key Words |
Inflammatory bowel disease; Tumour necrosis factor inhibitors; Hypertransaminasemia; Drug-related liver injury; Infliximab |
| Core Tip |
Anti-tumour-necrosis-factor (TNF) agents appear to be safe with a low risk of causing severe liver injury. Standard guidelines for the management of anti-TNF-related liver injury are lacking. Our approach, based on evidence from literature and our centre experience, highlights the need of a multidisciplinary approach and suggests liver biopsy as a key-point in the management decision. We particularly highlight that continuation of the anti-TNF treatment is usually possible, in view of the rarity of severe liver injury and the lack of alternative medical options in case of severe active inflammatory bowel disease. |
| Publish Date |
2014-12-18 17:08 |
| Citation |
Rossi RE, Parisi I, Despott EJ, Burroughs AK, O'Beirne J, Conte D, Hamilton MI, Murray CD. Anti-tumour necrosis factor agent and liver injury: Literature review, recommendations for management. World J Gastroenterol 2014; 20(46): 17352-17359 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i46/17352.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i46.17352 |
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