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Articles Published Processes
6/14/2024 8:01:41 AM | Browse: 66 | Download: 240
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Received |
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2024-03-29 19:40 |
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Peer-Review Started |
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2024-03-29 19:40 |
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To Make the First Decision |
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Return for Revision |
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2024-04-22 22:14 |
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Revised |
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2024-04-24 08:38 |
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Second Decision |
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2024-05-15 02:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-05-15 06:29 |
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Articles in Press |
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2024-05-15 06:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-05-23 03:57 |
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Publish the Manuscript Online |
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2024-06-14 08:01 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Ophthalmology |
| Manuscript Type |
Review |
| Article Title |
Whole-eye transplantation: Current challenges and future perspectives
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Anna Scarabosio, Pier Luigi Surico, Vlad Tereshenko, Rohan Bir Singh, Carlo Salati, Leopoldo Spadea, Glenda Caputo, Pier Camillo Parodi, Caterina Gagliano, Jonathan M Winograd and Marco Zeppieri |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Marco Zeppieri, MD, PhD, Doctor, Doctor, Department of Ophthalmology, University Hospital of Udine, p.le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it |
| Key Words |
Eye; Transplantation; Optic nerve; Nerve regeneration; Immunological tolerance |
| Core Tip |
Whole-eye transplantation remains a theoretical endeavor. Innovative technologies like bioengineered eyes holding promise for future breakthroughs. The foremost challenge is to restore the functional connectivity between the optic nerve and the retina. The challenge of reconnecting the optic neural axis is explained by its peculiar anatomical features where the cell bodies of the sensory neurons are located within the retina itself. Regeneration of axonal populations within the optic nerve from the occipital cortex towards the retina is physiologically not feasible. Research in cell and animal models may provide new frontiers to overcome these functional hurdles, with hopes that eye-sight can be restored with eye transplantation. |
| Publish Date |
2024-06-14 08:01 |
| Citation |
<p>Scarabosio A, Surico PL, Tereshenko V, Singh RB, Salati C, Spadea L, Caputo G, Parodi PC, Gagliano C, Winograd JM, Zeppieri M. Whole-eye transplantation: Current challenges and future perspectives. <i>World J Transplant</i> 2024; 14(2): 95009</p> |
| URL |
https://www.wjgnet.com/2220-3230/full/v14/i2/95009.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v14.i2.95009 |
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