Publication Name	World Journal of Hepatology
Manuscript ID	95047
Country	China

Received	2024-03-31 07:54
Peer-Review Started	2024-03-31 07:54
To Make the First Decision
Return for Revision	2024-08-15 21:01
Revised	2024-09-09 15:00
Second Decision	2024-10-10 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-10 09:37
Articles in Press	2024-10-10 09:37
Publication Fee Transferred	2024-10-14 04:50
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-28 00:22
Publish the Manuscript Online	2024-11-06 09:50

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Low level of hepatitis B viremia is associated with increased risk of hepatocellular carcinoma in compensated cirrhotic patients
Manuscript Source	Unsolicited Manuscript
All Author List	Wei-Chun Lin, Ke Lin, Ming-Kai Li, Xiao Liu, Yi-Fei Huang, Xing Wang and Bin Wu
ORCID	Author(s) ORCID Number Xing Wang http://orcid.org/0000-0002-5950-4591 Bin Wu http://orcid.org/0000-0001-9039-9681
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China 82070574
Corresponding Author	Bin Wu, PhD, Chief Physician, Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Guangzhou 510630, Guangdong Province, China. wubin6@mail.sysu.edu.cn
Key Words	Low level of hepatitis B viremia; Compensated cirrhosis; Hepatocellular carcinoma; Hepatic decompensation; Liver-related events
Core Tip	The need for antiviral therapy in patients with compensated cirrhosis and low-level hepatitis B viremia remains debated. This meta-analysis analyzed data from six cohort studies, revealing that low-level viremia in compensated cirrhosis is linked to a higher risk of hepatocellular carcinoma and an increased likelihood of cirrhosis decompensation and liver-related events. These findings support current guidelines for antiviral treatment, underscore the importance of vigilant cancer screening, and highlight the need for regular monitoring of viral levels.
Publish Date	2024-11-06 09:50
Citation	<p>Lin WC, Lin K, Li MK, Liu X, Huang YF, Wang X, Wu B. Low level of hepatitis B viremia is associated with increased risk of hepatocellular carcinoma in compensated cirrhotic patients. <i>World J Hepatol</i> 2024; 16(11): 1321-1330</p>
URL	https://www.wjgnet.com/1948-5182/full/v16/i11/1321.htm
DOI	https://dx.doi.org/10.4254/wjh.v16.i11.1321

Full Article (PDF)	WJH-16-1321-with-cover.pdf
PRISMA 2009 Checklist	95047-PRISMA-2009-Checklist.pdf
Manuscript File	95047_Auto_Edited_021947.docx
Answering Reviewers	95047-answering-reviewers.pdf
Audio Core Tip	95047-audio.mp3
Biostatistics Review Certificate	95047-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	95047-conflict-of-interest-statement.pdf
Copyright License Agreement	95047-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	95047-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	95047-non-native-speakers.pdf
Supplementary Material	95047-supplementary-material.pdf
Peer-review Report	95047-peer-reviews.pdf
Scientific Misconduct Check	95047-scientific-misconduct-check.png
Scientific Editor Work List	95047-scientific-editor-work-list.pdf
CrossCheck Report	95047-crosscheck-report.png
CrossCheck Report	95047-crosscheck-report.pdf