| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Gamma-aminobutyric acid enhances mir-21-5p loading into adipose-derived stem cell extracellular vesicles to alleviate myocardial ischemia-reperfusion injury via TXNIP regulation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Feng-Dan Wang, Yi Ding, Jian-Hong Zhou, En Zhou, Tian-Tian Zhang, Yu-Qi Fan, Qing He, Zong-Qi Zhang, Cheng-Yu Mao, Jun-Feng Zhang and Jing Zhou |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82200270 |
|
| Corresponding Author |
Jing Zhou, MM, Doctor, Doctor, Teacher, Department of Cardiology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, No. 280 Mohe Road, Baoshan District, Shanghai 200011, China. zj9hospital@163.com |
| Key Words |
Extracellular vesicles; Myocardial ischemia-reperfusion injury; Adipose-derived mesenchymal stem cells; Gamma-aminobutyric acid; Thioredoxin-interacting protein |
| Core Tip |
Extracellular vesicles secreted by adipose mesenchymal stem cells derived from subcutaneous inguinal adipose tissue under γ-aminobutyric acid induction demonstrate a pronounced inhibitory effect on mitochondrial oxidative stress and showcases a safeguarding impact on the cardiomyocytes. The protective effects may result from extracellular vesicle miR-21-5p targeting thioredoxin-interacting protein, regulating thioredoxin-interacting protein-thioredoxin complex formation and subsequent enhancing thioredoxin’s antioxidant activity. |
| Publish Date |
2024-10-25 02:40 |
| Citation |
<p>Wang FD, Ding Y, Zhou JH, Zhou E, Zhang TT, Fan YQ, He Q, Zhang ZQ, Mao CY, Zhang JF, Zhou J. Gamma-aminobutyric acid enhances mir-21-5p loading into adipose-derived stem cell extracellular vesicles to alleviate myocardial ischemia-reperfusion injury via TXNIP regulation. <i>World J Stem Cells</i> 2024; 16(10): 873-895</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v16/i10/873.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v16.i10.873 |
