| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Dentistry, Oral Surgery & Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
O-GlcNAc transferase regulates macrophage polarization in diabetic periodontitis: in vivo and in vitro study.
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ye-Ke Wu, Min Liu, Hong-Ling Zhou, Xiang He, Jing Wei, Wei-Han Hua, Hui-Jing Li, Qiang-Hua Yuan and Yun-Fei Xie |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Nature Science Foundation of China |
No. 81973684 |
| Nature Science Foundation of Sichuan Province |
No. 2023NSFSC1760 |
| Youth Talent Fund of Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital |
No. 2021QN09 |
|
| Corresponding Author |
Yun-Fei Xie, MD, Department of Nuclear Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, No. 32 West Section 2, 1st Ring Road, Chengdu 610072, Sichuan Province, China. xyfsub@126.com |
| Key Words |
Diabetic periodontitis; Macrophage polarization; O-linked β-N-acetylglucosamine; O-linked β-N-acetylglucosamine transferase; p38 |
| Core Tip |
OGT promotes the O-GlcNAcylation of p38 at S28, T241, and T347 sites and further activates the p38/MAPK pathway by phosphorylation itself at Y221. Inhibition of O-GlcNAcylation promotes M2-type polarization and inhibits M1-type polarization of macrophages, accelerating alveolar bone rebuild to decelerate DP progression. |
| Publish Date |
2025-01-21 09:26 |
| Citation |
<p>Wu YK, Liu M, Zhou HL, He X, Wei J, Hua WH, Li HJ, Yuan QH, Xie YF. O-GlcNAc transferase regulates macrophage polarization in diabetic periodontitis: in vivo and in vitro study.. <i>World J Diabetes</i> 2025; 16(3): 95092</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i3/95092.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i3.95092 |
