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Articles Published Processes
6/25/2024 10:11:57 AM | Browse: 316 | Download: 674
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Received |
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2024-04-02 22:26 |
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Peer-Review Started |
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2024-04-02 22:26 |
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First Decision by Editorial Office Director |
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2024-05-02 20:33 |
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Return for Revision |
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2024-05-02 20:33 |
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Revised |
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2024-05-04 17:12 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-05-20 02:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-05-20 06:49 |
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Articles in Press |
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2024-05-20 06:49 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-05-23 11:55 |
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Publish the Manuscript Online |
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2024-06-25 10:11 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Editorial |
| Article Title |
Priming mesenchymal stem cells to develop “super stem cells”
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Khawaja Husnain Haider |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Khawaja Husnain Haider, BPharm, BSc, PhD, Chairman, Full Professor, Professor, Department of Basic Sciences, Sulaiman AlRajhi University, AlMadina Road, AlQaseem 52736, Saudi Arabia. kh.haider@sr.edu.sa |
| Key Words |
Cell survival; Cell therapy; Preconditioning; Pre-treatment; Stem cells; Super stem cells |
| Core Tip |
Stem cell pre-treatment is a promising approach for accentuating their stemness and reparability and improving their resistance to apoptosis in the harsh microenvironment of the injured tissue. The current stem cell pre-treatment protocols allow for enhancing their therapeutic efficacy to surmount the limitations of mesenchymal stem cells (MSCs), i.e., mobility, survival, engraftment, and paracrine activity. Besides a novel sub-cellular preconditioning strategy, the combinative preconditioning approach exposing the cells to a proinflammatory milieu under hypoxia improves MSCs’ immunoregulatory potential. Refining a combinatorial pre-treatment protocol using a well-defined mechanistic understanding may allow the exploitation of the full benefits of the pre-treated “super MSCs” for enhanced stemness, functionality, and reparability, including immunosuppressive and immunomodulatory properties. |
| Publish Date |
2024-06-25 10:11 |
| Citation |
Haider KH. Priming mesenchymal stem cells to develop “super stem cells”. World J Stem Cells 2024; 16(6): 623-640 |
| URL |
https://www.wjgnet.com/1948-0210/full/v16/i6/623.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v16.i6.623 |
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