Publication Name	World Journal of Diabetes
Manuscript ID	95206
Country	Mexico

Received	2024-04-04 04:56
Peer-Review Started	2024-04-04 04:56
To Make the First Decision
Return for Revision	2024-05-11 08:04
Revised	2024-05-28 07:58
Second Decision	2024-06-17 06:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-06-26 07:38
Articles in Press	2024-06-26 07:38
Publication Fee Transferred	2024-07-09 02:50
Edit the Manuscript by Language Editor	2024-07-13 16:21
Typeset the Manuscript	2024-07-18 09:49
Publish the Manuscript Online	2024-07-26 06:56

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Endocrinology & Metabolism
Manuscript Type	Case Control Study
Article Title	Autoantibodies against beta cell to predict early insulin requirements in pediatric patients with clinically diagnosed type 2 diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Jorge M Molina, Patricia G Medina, Rita A Gomez, Julia R Herrera, Nancy L Martínez, Brenda Hernández and Yesenia García
ORCID	Author(s) ORCID Number Jorge M Molina http://orcid.org/0000-0001-5311-4528
Funding Agency and Grant Number	Funding Agency Grant Number Mexican Federal Funds HIM 2018/068 SSA152
Corresponding Author	Jorge M Molina, PhD, Doctor, Doctor, Department of Endocrinology, Children’s Hospital Federico Gomez, Dr. Márquez 162, Colonia Doctores, Cuauhtemoc, Mexico 06720, Mexico. dereck79@live.com.mx
Key Words	Diabetes; Obesity; Adolescents; Autoimmunity; Beta cell; Insulin requirements
Core Tip	We found that patients with type 2 diabetes in pediatric age show a more aggressive phenotype of the disease, with a significant depletion of beta cell function, and where antibodies against pancreatic beta cells were associated with lower levels of insulin and C-peptide conferring a higher risk of early dependence on exogenous insulin. Therefore, in a pediatric patient with type 2 diabetes mellitus phenotype, the determination of pancreatic antibodies can be a clinical tool to predict early insulin requirements, leading to closer control of the disease to avoid chronic complications.
Publish Date	2024-07-26 06:56
Citation	<p>Molina JM, Medina PG, Gomez RA, Herrera JR, Martínez NL, Hernández B, García Y. Autoantibodies against beta cell to predict early insulin requirements in pediatric patients with clinically diagnosed type 2 diabetes. <i>World J Diabetes</i> 2024; 15(8): 1717-1725</p>
URL	https://www.wjgnet.com/1948-9358/full/v15/i8/1717.htm
DOI	https://dx.doi.org/10.4239/wjd.v15.i8.1717

Full Article (PDF)	WJD-15-1717-with-cover.pdf
STROBE Statement	95206-STROBE-statement.pdf
Manuscript File	95206_Auto_Edited_071513.docx
Answering Reviewers	95206-answering-reviewers.pdf
Audio Core Tip	95206-audio.mp3
Biostatistics Review Certificate	95206-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	95206-conflict-of-interest-statement.pdf
Copyright License Agreement	95206-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	95206-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	95206-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	95206-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	95206-non-native-speakers.pdf
Peer-review Report	95206-peer-reviews.pdf
Journal Editor-in-Chief Review Report	95206-journal-editor-in-chief.pdf
Scientific Misconduct Check	95206-scientific-misconduct-check.jpg
Scientific Editor Work List	95206-scientific-editor-work-list.pdf
CrossCheck Report	95206-crosscheck-report.pdf