Publication Name	World Journal of Gastroenterology
Manuscript ID	95207
Country	Spain

Received	2024-04-04 06:41
Peer-Review Started	2024-04-04 06:41
To Make the First Decision
Return for Revision	2024-08-01 21:54
Revised	2024-08-30 08:18
Second Decision	2024-09-12 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-12 03:34
Articles in Press	2024-09-12 03:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-12-02 13:41
Typeset the Manuscript	2024-12-12 07:58
Publish the Manuscript Online	2024-12-20 03:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	In silico analysis of lncRNA-miRNA-mRNA signatures related to sorafenib effectiveness in liver cancer cells
Manuscript Source	Unsolicited Manuscript
All Author List	Patricia de la Cruz-Ojeda, Ester Parras-Martínez, Raquel Rey-Pérez and Jordi Muntané
ORCID	Author(s) ORCID Number Jordi Muntané http://orcid.org/0000-0002-6744-1121
Funding Agency and Grant Number	Funding Agency Grant Number Instituto de Salud Carlos III (ISCiii) PI19/01266 and PI22/00857 Consejería de Salud y Familias (Junta de Andalucía) PI-0216-2020 and PIP-0215-2020 Biomedical Research Network Center for Liver and Digestive Diseases (CIBERehd) founded by the ISCIII and co-financed by European Regional Development Fund “A way to achieve Europe” ERDF
Corresponding Author	Jordi Muntané, PhD, Research Associate, Department of Oncology Surgery, Cell Therapy and Organ Transplantation, Institute of Biomedicine of Seville, Virgen del Rocio University Hospital, Avn. Manuel Siurot S/N, Seville 41013, Spain. jmuntane-ibis@us.es
Key Words	Cell culture; Hepatocellular carcinoma; Non-coding RNA; RNAseq; Sorafenib
Core Tip	In the current study, we investigated the differential lncRNA-miRNA-mRNA regulatory axes in HepG2 and SNU449 under Sorafenib treatment. The study identified lncRNA-miRNA regulatory axes leading to increased expression mRNA with positive (SMAD7, TIRARP, TFAP4, FAXDC2 and ADRB2) and negative (VEGFA) therapeutic effects in HepG2 and SNU449 under Sorafenib treatment.
Publish Date	2024-12-20 03:53
Citation	<p>de la Cruz-Ojeda P, Parras-Martínez E, Rey-Pérez R, Muntané J. In silico analysis of lncRNA-miRNA-mRNA signatures related to sorafenib effectiveness in liver cancer cells. <i>World J Gastroenterol</i> 2025; 31(3): 95207</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i3/95207.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i3.95207

Full Article (PDF)	WJG-31-95207-with-cover.pdf
Manuscript File	95207_Auto_Edited_013809.docx
Answering Reviewers	95207-answering-reviewers.pdf
Audio Core Tip	95207-audio.m4a
Biostatistics Review Certificate	95207-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	95207-conflict-of-interest-statement.pdf
Copyright License Agreement	95207-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	95207-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	95207-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	95207-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	95207-non-native-speakers.pdf
Supplementary Material	95207-supplementary-material.pdf
Peer-review Report	95207-peer-reviews.pdf
Scientific Misconduct Check	95207-scientific-misconduct-check.png
Scientific Editor Work List	95207-scientific-editor-work-list.pdf
CrossCheck Report	95207-crosscheck-report.pdf