Publication Name	World Journal of Clinical Cases
Manuscript ID	95231
Country	China

Received	2024-04-05 03:59
Peer-Review Started	2024-04-05 03:59
To Make the First Decision
Return for Revision	2024-04-30 06:00
Revised	2024-05-12 14:40
Second Decision	2024-05-23 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-05-23 09:26
Articles in Press	2024-05-23 09:26
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-05-28 04:58
Typeset the Manuscript	2024-07-18 07:41
Publish the Manuscript Online	2024-07-23 06:37

ISSN	2307-8960 (online)
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Category	Pathology
Manuscript Type	Editorial
Article Title	Paired box proteins as diagnostic biomarkers for endocervical adenocarcinoma
Manuscript Source	Invited Manuscript
All Author List	Jia-Hui Zhou and Xiang-Ning Zhang
ORCID	Author(s) ORCID Number Jia-Hui Zhou http://orcid.org/0000-0002-9735-685x Xiang-Ning Zhang http://orcid.org/0000-0002-7875-5548
Funding Agency and Grant Number
Corresponding Author	Xiang-Ning Zhang, MD, PhD, Associate Professor, Pathophysiology Department, Guangdong Medical university, No. 1 Xincheng Avenue, Songshan Lake Scientific and Industrial Park, Dongguan 523808, Guangdong Province, China. zhangxn_2006@126.com
Key Words	Cervical adenocarcinoma; Diagnostic biomarker; Paired box protein 8; Embryogenesis; Transcription factor
Core Tip	Paired box proteins (PAXs) are a family of transcription factors that play an important role in the embryogenesis of different tissues through the regulation of gene expression. PAX 2, 5, and 8 are expressed in the sites of mesonephric tissues, and their deregulation contributes to the genesis of urogenital tumors such as cervical and ovarian cancers. Immunohistochemical staining and in situ hybridization tests revealed that the specimens of endocervical adenocarcinoma were positive for the transcription factor PAX8 and human papillomavirus. It is proposed that combined with mucin of glandular tumor, PAX8 can be used as a diagnostic marker for cervical adenocarcinoma.
Publish Date	2024-07-23 06:37
Citation	<p>Zhou JH, Zhang XN. Paired box proteins as diagnostic biomarkers for endocervical adenocarcinoma. <i>World J Clin Cases</i> 2024; 12(26): 5854-5858</p>
URL	https://www.wjgnet.com/2307-8960/full/v12/i26/5854.htm
DOI	https://dx.doi.org/10.12998/wjcc.v12.i26.5854

Full Article (PDF)	WJCC-12-5854-with-cover.pdf
Manuscript File	95231_Auto_Edited_030220.docx
Answering Reviewers	95231-answering-reviewers.pdf
Audio Core Tip	95231-audio.mp3
Conflict-of-Interest Disclosure Form	95231-conflict-of-interest-statement.pdf
Copyright License Agreement	95231-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	95231-non-native-speakers.pdf
Peer-review Report	95231-peer-reviews.pdf
Scientific Misconduct Check	95231-scientific-misconduct-check.png
Scientific Editor Work List	95231-scientific-editor-work-list.pdf
CrossCheck Report	95231-crosscheck-report.pdf