| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Network pharmacology study and in vitro experimental validation of Xiaojianzhong decoction against gastric cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Guo-Qing Chen, Yi Nan, Na Ning, Shi-Cong Huang, Yu-Ting Bai, Zi-Ying Zhou, Gu Qian, Wei-Qiang Li and Ling Yuan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the West Light Foundation of the Ningxia Key Research and Development Program |
2023BEG02015 |
| High-level Key Discipline Construction Project of State Administration of Traditional Chinese Medicine |
2022-226 |
| Talent Development Projects of Young Qihuang of National Administration of Traditional Chinese Medicine |
2020-218 |
| National Natural Science Foundation of China |
82374261 |
|
| Corresponding Author |
Ling Yuan, MD, Full Professor, College of Pharmacy, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China. 20080017@nxmu.edu.cn |
| Key Words |
Xiaojianzhong decoction; Gastric cancer; Network pharmacology; Molecular mechanism; In vitro experiment |
| Core Tip |
We analyzed the mechanism and target of Xiaojianzhong decoction (XJZ) in the treatment of gastric cancer (GC) through network pharmacology and bioinformatics. Subsequently, we verified the impact of XJZ treatment on the proliferative ability of GC cells through various assays, including CCK-8, apoptosis, cycle, and colony formation. Additionally, we performed Western blotting and real-time quantitative-PCR to assess the expression of the core protein and mRNA of the hub gene. This provided a new idea and scientific basis for further research on the molecular mechanisms of the therapeutic effects of XJZ in the treatment of GC. |
| Publish Date |
2024-09-09 08:41 |
| Citation |
<p>Chen GQ, Nan Y, Ning N, Huang SC, Bai YT, Zhou ZY, Qian G, Li WQ, Yuan L. Network pharmacology study and in vitro experimental validation of Xiaojianzhong decoction against gastric cancer. <i>World J Gastrointest Oncol</i> 2024; 16(9): 3932-3954</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i9/3932.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i9.3932 |
