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Articles Published Processes
7/12/2024 3:55:59 PM | Browse: 88 | Download: 523
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Received |
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2024-04-05 20:44 |
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Peer-Review Started |
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2024-04-05 20:44 |
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First Decision by Editorial Office Director |
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2024-04-24 01:00 |
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Return for Revision |
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2024-04-24 01:00 |
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Revised |
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2024-05-05 05:23 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-05-22 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-05-22 07:45 |
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Articles in Press |
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2024-05-22 07:45 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-06-05 06:36 |
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Publish the Manuscript Online |
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2024-07-12 15:55 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Prognostic significance of exportin-5 in hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hao Li, Fei Li, Bo-Shen Wang and Bao-Li Zhu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research Project of Jiangsu Health Committee |
No. M2022083 |
| Natural Science Foundation of Jiangsu Province |
No. BK20230742 |
| Open Project of Key Laboratory of Environmental Medicine Engineering of Ministry of Education |
No. 2022EME001 |
| Laboratory of Jiangsu Provincial Medical Key Discipline |
No. ZDXK202249 |
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| Corresponding Author |
Bao-Li Zhu, Doctor, Associate Chief Physician, Chairman, Professor, Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, No. 172 Jiangsu Road, Nanjing 210000, Jiangsu Province, China. zhublcdc@sina.com |
| Key Words |
Exportin-5 expression; Hepatocellular carcinoma; Prognostic biomarker; In vitro experiments; Bioinformatic analysis |
| Core Tip |
This study reveals the pivotal role of exportin-5 (XPO5), a miRNA transport protein, in the progression and prognosis of hepatocellular carcinoma (HCC). Bioinformatic databases and in vitro assays demonstrated that XPO5 expression was upregulated in HCC tissues, correlating with aggressive tumor features and poor patient outcomes. Furthermore, XPO5 levels influenced immune cell behavior, particularly in T cells and macrophages, suggesting its potential as a target for immunotherapy. This study suggests that XPO5 could be used as a biomarker for the prognosis of HCC and as a novel therapeutic target. |
| Publish Date |
2024-07-12 15:55 |
| Citation |
Li H, Li F, Wang BS, Zhu BL. Prognostic significance of exportin-5 in hepatocellular carcinoma. World J Gastrointest Oncol 2024; 16(7): 3069-3081 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i7/3069.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i7.3069 |
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