Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	95279
Country	China

Received	2024-04-07 03:31
Peer-Review Started	2024-04-07 03:32
To Make the First Decision
Return for Revision	2024-07-25 09:17
Revised	2024-08-06 17:06
Second Decision	2024-09-03 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-03 09:00
Articles in Press	2024-09-03 09:00
Publication Fee Transferred	2024-09-04 05:26
Edit the Manuscript by Language Editor	2024-09-11 10:50
Typeset the Manuscript	2024-09-18 02:17
Publish the Manuscript Online	2024-09-26 10:17

ISSN	1948-5204 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Jianpi-Huatan-Huoxue-Anshen ameliorates gastrointestinal inflammation and microecology in chemotherapy-treated mice transplanted with H22 hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Ya-Nan Wang, Xiang-Yang Zhai, Zheng Wang, Chun-Ling Gao, Sui-Cai Mi, Wen-Li Tang, Xue-Min Fu, Huai-Bang Li, Li-Feng Yue, Peng-Fei Li and Sheng-Yan Xi
ORCID	Author(s) ORCID Number Chun-Ling Gao http://orcid.org/0000-0003-1720-9890 Sui-Cai Mi http://orcid.org/0000-0002-1378-9915 Sheng-Yan Xi http://orcid.org/0000-0002-8315-6742
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Xiamen, China 3502Z20227171 the Young Investigator Research Program of Xiang’an Hospital of Xiamen University XAH23005 the Traditional Chinese Medicine Foundation of Xiamen XWZY-2023-0103 Natural Science Foundation of Fujian, China 2018J01136 National Natural Science Foundation of China 81202659
Corresponding Author	Sheng-Yan Xi, Doctor, PhD, Associate Chief Physician, Associate Professor, Department of TCM, Xiang’an Hospital, School of Medicine, Xiamen University, No. 4221-122 Xiang’an Nan Road, Xiamen 361102, Fujian Province, China. xishengyan@xmu.edu.cn
Key Words	Chinese medicine; Chemotherapy; H22 hepatocellular carcinoma; Intestinal barrier function; Intestinal microecological balance
Core Tip	Jianpi-Huatan-Huoxue-Anshen formula (Tzu-Chi cancer-antagonizing & life-protecting II decoction) down-regulates NF-κB pathway and the release of inflammatory factors, alleviates intestinal inflammation, improves intestinal morphology, reduces intestinal barrier damage, and keeps the dynamic balance of intestinal microecology. These results reveal the potential role and advantages of Chinese herbal compounds in improving the unbalanced microenvironment after cancer chemotherapy.
Publish Date	2024-09-26 10:17
Citation	<p>Wang YN, Zhai XY, Wang Z, Gao CL, Mi SC, Tang WL, Fu XM, Li HB, Yue LF, Li PF, Xi SY. Jianpi-Huatan-Huoxue-Anshen ameliorates gastrointestinal inflammation and microecology in chemotherapy-treated mice transplanted with H22 hepatocellular carcinoma. <i>World J Gastrointest Oncol</i> 2024; 16(10): 4209-4231</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i10/4209.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i10.4209

Full Article (PDF)	WJGO-16-4209-with-cover.pdf
The ARRIVE Guidelines	95279-The-ARRIVE-Guidelines.pdf
Manuscript File	95279_Auto_Edited_040213.docx
Answering Reviewers	95279-answering-reviewers.pdf
Audio Core Tip	95279-audio.m4a
Biostatistics Review Certificate	95279-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	95279-conflict-of-interest-statement.pdf
Copyright License Agreement	95279-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	95279-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	95279-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	95279-non-native-speakers.pdf
Supplementary Material	95279-supplementary-material.docx
Peer-review Report	95279-peer-reviews.pdf
Scientific Misconduct Check	95279-scientific-misconduct-check.png
Scientific Editor Work List	95279-scientific-editor-work-list.pdf
CrossCheck Report	95279-crosscheck-report.png
CrossCheck Report	95279-crosscheck-report.pdf