Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	95282
Country	China

Received	2024-04-24 10:34
Peer-Review Started	2024-04-24 10:34
To Make the First Decision
Return for Revision	2024-05-15 09:11
Revised	2024-05-17 02:09
Second Decision	2024-05-20 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-05-20 06:17
Articles in Press	2024-05-20 06:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-06-15 09:47
Publish the Manuscript Online	2024-07-12 15:55

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Meta-Analysis
Article Title	Clinical benefits of transarterial chemoembolization combined with tyrosine kinase and immune checkpoint inhibitors for unresectable hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Feng Han, Xiao-Han Wang and Chen-Zhou Xu
ORCID	Author(s) ORCID Number Chen-Zhou Xu http://orcid.org/0009-0009-9227-7210
Funding Agency and Grant Number	Funding Agency Grant Number Jiaxing Public Welfare Research Project 2022AD30046
Corresponding Author	Chen-Zhou Xu, MM, Doctor, Doctor, Department of Gastroenterology, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, No. 1882 Zhonghuan South Road, Jiaxing 314001, Zhejiang Province, China. jxsdyyyxcz@zjxu.edu.cn
Key Words	Transarterial chemoembolization; Tyrosine kinase inhibitors; Immune checkpoint inhibitors; Hepatocellular carcinoma; Meta-analysis
Core Tip	Consensus regarding the treatment of unresectable hepatocellular carcinoma (HCC) currently remains lacking. The triple combination therapy of transarterial chemoembolization with tyrosine kinase and immune checkpoint inhibitors has attracted significant attention as an aggressive treatment strategy and has been used for treatment in recent years. We conducted a systematic review and updated meta-analysis to verify the clinical benefits and adverse effects of triple therapy in 29 studies with 1754 patients with unresectable HCC. The complete response, objective response rate, disease control rate, overall survival, progression-free survival, and adverse events induced by the triple therapy were evaluated.
Publish Date	2024-07-12 15:55
Citation	<p>Han F, Wang XH, Xu CZ. Clinical benefits of transarterial chemoembolization combined with tyrosine kinase and immune checkpoint inhibitors for unresectable hepatocellular carcinoma. <i>World J Gastrointest Oncol</i> 2024; 16(7): 3308-3320</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i7/3308.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i7.3308

Full Article (PDF)	WJGO-16-3308-with-cover.pdf
PRISMA 2009 Checklist	95282-PRISMA-2009-Checklist.pdf
Manuscript File	95282_Auto_Edited-YJP.docx
Answering Reviewers	95282-answering-reviewers.pdf
Audio Core Tip	95282-audio.aac
Biostatistics Review Certificate	95282-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	95282-conflict-of-interest-statement.pdf
Copyright License Agreement	95282-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	95282-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	95282-non-native-speakers.pdf
Peer-review Report	95282-peer-reviews.pdf
Scientific Misconduct Check	95282-scientific-misconduct-check.png
Scientific Editor Work List	95282-scientific-editor-work-list.pdf
CrossCheck Report	95282-crosscheck-report.png
CrossCheck Report	95282-crosscheck-report.pdf