| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhen Huang, Fan-Ying Meng, Lin-Zhu Lu, Qian-Qian Guo, Chang-Jun Lv, Nian-Hua Tan, Zhe Deng, Jun-Yi Chen, Zi-Shu Zhang, Bo Zou, Hong-Ping Long, Qing Zhou, Sha Tian, Si Mei and Xue-Fei Tian |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82074450 |
| Education Department of Hunan Province |
21A0243, 21B0374 |
| Research Project of "Academician Liu Liang Workstation" of Hunan University of Traditional Chinese Medicine |
21YS003 |
| Hunan Administration of Traditional Chinese Medicine |
B2023001 and B2023009 |
| Hunan Provincial Natural Science Foundation of China |
2023JJ40481 |
| Education Department of Hunan Province |
22B0397 and 22B0392 |
|
| Corresponding Author |
Xue-Fei Tian, College of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, No. 300 Xueshi Road, Changsha 410208, Hunan Province, China. 003640@hnucm.edu.cn |
| Key Words |
Calculus bovis; M2 tumor-associated macrophage polarization; Liver cancer; Wnt/β-catenin pathway; The tumor microenvironment |
| Core Tip |
CB, a valued herb in traditional Chinese medicine (TCM), has shown definite anti-liver cancer effects in vivo experiments. Analyzing the composition of CB and using network pharmacology for target prediction, CB exhibits anti-liver cancer effects by affecting immune related pathways in the tumor microenvironment. Through transcriptome sequencing, we further showed that regulating M2-type polarization of TAMs is a more specific reason for the effect of CB. In vitro studies, the Wnt/β-catenin pathway is a crucial mechanism by which CB regulates M2-type polarization of TAMs. The entire study provides evidence to the research of anti-liver cancer drugs. |
| Publish Date |
2024-07-29 02:31 |
| Citation |
<p>Huang Z, Meng FY, Lu LZ, Guo QQ, Lv CJ, Tan NH, Deng Z, Chen JY, Zhang ZS, Zou B, Long HP, Zhou Q, Tian S, Mei S, Tian XF. Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer. <i>World J Gastroenterol</i> 2024; 30(29): 3511-3533</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i29/3511.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i29.3511 |
