| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
BCAR3 and BCAR3-related competing endogenous RNA expression in hepatocellular carcinoma and their prognostic value
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui-Qin Shi, Shu Huang, Xin-Yue Ma, Zhen-Ju Tan, Rui Luo, Bei Luo, Wei Zhang, Lei Shi, Xiao-Lin Zhong, Mu-Han Lü, Xia Chen and Xiao-Wei Tang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xiao-Wei Tang, MD, PhD, Associate Professor, Postdoc, Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Jiangyang Region, Luzhou 646000, Sichuan Province, China. solitude5834@hotmail.com |
| Key Words |
Hepatocellular carcinoma; Breast cancer anti-estrogen-resistant protein 3; Bioinformatics; Prognosis; Immunoassay |
| Core Tip |
BCAR3 gene was over-expressed in a variety of malignant tumors, and its high expression was significantly associated with poor prognosis of cancer patients. In hepatocellular carcinoma (HCC), the expression of BCAR3 was observably higher in cancer tissues than in normal tissues, and the expression level was higher in HCC tissues with TP53 mutation compared to those without. BCAR3 was positively correlated with a variety of immune cells in HCC tissues, and might play an important role in the immune micro-environment of tumors. In addition, the BCAR3/miR-19b-3p/RAB30-DT competing endogenous RNA regulatory axis may be involved in the development of HCC. |
| Publish Date |
2024-07-12 15:55 |
| Citation |
Shi HQ, Huang S, Ma XY, Tan ZJ, Luo R, Luo B, Zhang W, Shi L, Zhong XL, Lü MH, Chen X, Tang XW. BCAR3 and BCAR3-related competing endogenous RNA expression in hepatocellular carcinoma and their prognostic value. World J Gastrointest Oncol 2024; 16(7): 3082-3096 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i7/3082.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i7.3082 |
