| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Glycolysis-related five-gene signature correlates with prognosis and immune infiltration in gastric cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiang-Yu Meng, Dong Yang, Bao Zhang, Tao Zhang, Zhi-Chao Zheng and Yan Zhao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Training Program of the National Natural Science Foundation of China |
2021-ZLLH-05 |
| National Cancer Center Climbing Fund |
NCC201906B02 |
| Shenyang Municipal Science and Technology Public Health Research and Development Special Project |
21-172-9-03, 22-321-33-53 |
| Dalian University of Technology-Liaoning Cancer Hospital Medical Engineering Cross-Union Fund |
LD202309 |
|
| Corresponding Author |
Yan Zhao, MD, Doctor, Doctor, Department of Gastric Surgery, Cancer Hospital of China Medical University/Liaoning Cancer Hospital & Institute/The Liaoning Provincial Key Laboratory of Interdisciplinary Research on Gastrointestinal Tumor Combining Medicine with Engineering, No. 44 Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, China. doctorzhaoyan@126.com |
| Key Words |
Glycolysis; Tumor microenvironment; Immune infiltration; Prognosis; Gastric cancer |
| Core Tip |
A five-gene signature consisting of syndecan 2, versican, malic enzyme 1, pyruvate carboxylase, and SRY-box transcription factor 9 was constructed. Based on their risk scores, the patients were stratified into high- or low-glycolysis groups. The patients with high glycolysis were significantly poorer. The high-glycolysis patients revealed dysregulation of pancreas beta cells and estrogen late pathways, while low-glycolysis patients showed associations with Myc targets, oxidative phosphorylation, mechanistic target of rapamycin complex 1 signaling, and G2M checkpoint pathways. A significant correlation between different glycolysis statuses and multiple immune cell infiltrations was observed. The high glycolysis status was associated with lower tumor mutational burden, higher incidence of microsatellite instability-high, as well as reduced chemosensitivity among gastric cancer patients. |
| Publish Date |
2024-07-12 15:55 |
| Citation |
<p>Meng XY, Yang D, Zhang B, Zhang T, Zheng ZC, Zhao Y. Glycolysis-related five-gene signature correlates with prognosis and immune infiltration in gastric cancer. <i>World J Gastrointest Oncol</i> 2024; 16(7): 3097-3117</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i7/3097.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i7.3097 |
