Publication Name	World Journal of Meta-Analysis
Manuscript ID	95417
Country	United States

Received	2024-04-09 18:37
Peer-Review Started	2024-04-09 18:37
To Make the First Decision
Return for Revision	2024-07-09 20:56
Revised	2024-07-20 18:08
Second Decision	2024-07-29 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-29 07:57
Articles in Press	2024-07-29 07:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-07-30 09:31
Publish the Manuscript Online	2024-09-13 09:40

ISSN	2308-3840 (online)
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Category	Neurosciences
Manuscript Type	Review
Article Title	Mechanisms of vascular injury in neurotrauma: A critical review of the literature
Manuscript Source	Invited Manuscript
All Author List	Jonathan Willman, Annu Lisa Kurian and Brandon Lucke-Wold
ORCID	Author(s) ORCID Number Jonathan Willman http://orcid.org/0000-0002-7205-7482 Brandon Lucke-Wold http://orcid.org/0000-0001-6577-4080
Funding Agency and Grant Number
Corresponding Author	Jonathan Willman, BSc, N/A, N/A, College of Medicine, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, United States. jonathanwillman@ufl.edu
Key Words	Neurotrauma; Neurovascular injury; Primary neurotrauma; Secondary neurotrauma; Traumatic brain injury; Traumatic spinal cord injury; Glymphatic system; Vascular Injury
Core Tip	Primary neurotrauma is an initial mechanical insult to the central nervous system. Secondary neurotrauma involves metabolic and cellular derangements that occur days to months after the initial insult. Together, this neurotrauma disrupts cerebral autoregulation and neurovascular coupling, leading to derangements in neurovascular flow and blood-brain barrier dysfunction. Similarly, the glymphatic system, responsible for clearing waste products through the perivascular space, becomes impaired following neurotrauma, leading to increased protein deposition and cognitive decline. Emerging therapeutics focus on reducing neuroedema, decreasing blood-brain barrier dysfunction, and promoting neuroregeneration.
Publish Date	2024-09-13 09:40
Citation	<p>Willman J, Kurian AL, Lucke-Wold B. Mechanisms of vascular injury in neurotrauma: A critical review of the literature. <i>World J Meta-Anal</i> 2024; 12(3): 95417</p>
URL	https://www.wjgnet.com/2308-3840/full/v12/i3/95417.htm
DOI	https://dx.doi.org/10.13105/wjma.v12.i3.95417

Full Article (PDF)	WJMA-12-95417-with-cover.pdf
Manuscript File	95417_Auto_Edited_004148.docx
Answering Reviewers	95417-answering-reviewers.pdf
Audio Core Tip	95417-audio.mp3
Conflict-of-Interest Disclosure Form	95417-conflict-of-interest-statement.pdf
Copyright License Agreement	95417-copyright-assignment.pdf
Peer-review Report	95417-peer-reviews.pdf
Scientific Misconduct Check	95417-scientific-misconduct-check.png
Scientific Editor Work List	95417-scientific-editor-work-list.pdf
CrossCheck Report	95417-crosscheck-report.pdf
CrossCheck Report	95417-crosscheck-report.png