| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Endoplasmic reticulum stress and forkhead box protein O1 inhibition mediate palmitic acid and high glucose-induced β-cell dedifferentiation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Kun Wang, Chu-Chu Kong, Ting-Yan Yu, Hui-Song Sun, Lu Yang, Ying Sun, Ming-Yu Li and Wei Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of China |
No. 81471081 |
| Natural Science Foundation of Fujian Province |
No. 2023D009 |
| Natural Science Foundation of Xiamen City |
No. 3502Z202373104 |
| Natural Science Foundation of Xiamen City |
No. 3502Z20227162 |
| Scientific Research Foundation for Advanced Talents, Xiang’an Hospital of Xiamen University |
No. PM201809170005 |
|
| Corresponding Author |
Wei Wang, Chief Physician, MD, Professor, Department of Endocrinology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2000 Xiang’an East Road, Xiang’an District, Xiamen 361102, Fujian Province, China. wwei19742007@hotmail.com |
| Key Words |
β-cell dedifferentiation; High glucose and palmitic acid; Forkhead box O1; RNA-sequencing; Endoplasmic reticulum stress |
| Core Tip |
β-cell dedifferentiation is one of the mechanisms of β cell dysfunction, but the underlying mechanisms remain unclear. In this study, we established an in vitro model of β-cell dedifferentiation induced by high-glucose and palmitic acid, and showed that the inhibition of forkhead box O1 can further enhance these phenomena. We found that high glucose and palmitic acid treatments significantly downregulated the expression of β-cell-specific markers and upregulated the expression of β-cell-disabling genes and endocrine precursor cell marker genes by RNA-sequencing, and that endoplasmic reticulum stress is the key to β-cell dedifferentiation. This study will be beneficial for investigating the mechanism of β-cell dysfunction caused by dedifferentiation. |
| Publish Date |
2025-04-25 07:54 |
| Citation |
<p>Wang LK, Kong CC, Yu TY, Sun HS, Yang L, Sun Y, Li MY, Wang W. Endoplasmic reticulum stress and forkhead box protein O1 inhibition mediate palmitic acid and high glucose-induced β-cell dedifferentiation. <i>World J Diabetes</i> 2025; 16(5): 95431</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i5/95431.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i5.95431 |
