Publication Name	World Journal of Gastroenterology
Manuscript ID	9550
Country	Italy

Received	2014-02-17 14:29
Peer-Review Started	2014-02-18 02:50
To Make the First Decision	2014-03-27 21:17
Return for Revision	2014-03-31 10:05
Revised	2014-04-28 00:00
Second Decision	2014-05-26 21:30
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-26 21:49
Articles in Press	2014-05-26 22:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-18 15:27
Publish the Manuscript Online	2014-10-01 20:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Hepatocellular carcinoma in nonalcoholic fatty liver: Role of environmental and genetic factors
Manuscript Source	Invited Manuscript
All Author List	Paola Dongiovanni, Stefano Romeo and Luca Valenti
Funding Agency and Grant Number
Corresponding Author	Luca Valenti, MD, Assistant Professor, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Pad. Granelli via F Sforza 35, 20122 Milano, Italy. luca.valenti@unimi.it
Key Words	Nonalcoholic fatty liver disease; Steatosis; Hepatocellular carcinoma; Cirrhosis; Fibrogenesis; Liver disease; Genetics; Single nucleotide polymorphism; Patatin-like phospholipase domain-containing 3
Core Tip	Nonalcoholic fatty liver disease (NAFLD) associated with obesity, insulin resistance, and type 2 diabetes, is an increasingly recognized trigger of hepatocellular carcinoma (HCC), even in non-cirrhotic livers. The role of inherited factors seems magnified in fatty liver. The common I148M variant of the PNPLA3 gene influencing hepatic lipid metabolism has been associated with HCC. Rare loss-of-function mutations in apolipoprotein B resulting in very low density lipoproteins hepatic retention and in telomerase reverse transcriptase influencing senescence have been linked to HCC in NAFLD. Hepatic stellate cells senescence has also been suggested to bridge tissue aging with microbiota alterations in the pathogenesis of obesity-related HCC.
Publish Date	2014-10-01 20:25
Citation	Dongiovanni P, Romeo S, Valenti L. Hepatocellular carcinoma in nonalcoholic fatty liver: Role of enviromental and genetic factors. World J Gastroenterol 2014; 20(36): 12945-12955
URL	http://www.wjgnet.com/1007-9327/full/v20/i36/12945.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i36.12945

Full Article (PDF)	WJG-20-12945.pdf
Full Article (Word)	WJG-20-12945.doc
Manuscript File	9550-Review.doc
Answering Reviewers	9550-Answering reviewers.pdf
Copyright License Agreement	9550-Copyright assignment.pdf
Peer-review Report	9550-Peer review.pdf
Scientific Misconduct Check	9550-CrossCheck.jpg
Scientific Editor Work List	9550-Scientific editor work list.pdf