| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Molecular mechanisms of Buqing granule for the treatment of diabetic retinopathy: Network pharmacology analysis and experimental validation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Fan Yang, Ling Yuan, Xiang-Yang Li, Qian Liu, Wen-Jie Jiang, Tai-Qiang Jiao, Jia-Qing Li, Meng-Yi Ye, Yang Niu and Yi Nan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81960836 |
| Ningxia Natural Science Foundation |
2020AAC03126 |
| Ningxia Higher Education Scientific Research Project |
NGY2020045 |
|
| Corresponding Author |
Yi Nan, MD, Professor, Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China. 20080011@nxmu.edu.cn |
| Key Words |
Diabetic retinopathy; Network pharmacology; Animal models; Oxidative stress; Inflammatory |
| Core Tip |
In this study, we constructed a diabetic retinopathy (DR) model in Sprague-Dawley rats and combined network pharmacology and in vivo experiments to thoroughly investigate the therapeutic efficacy of Buqing granule in DR and their mechanism of action. The experimental data showed that Buqing granule could significantly reduce oxidative stress and inflammatory damage, thus delaying DR. This finding not only deepens our understanding of DR pathogenesis, but also provides new ideas and potential therapeutic targets for future innovation in DR treatment. |
| Publish Date |
2024-08-27 15:11 |
| Citation |
<p>Yang YF, Yuan L, Li XY, Liu Q, Jiang WJ, Jiao TQ, Li JQ, Ye MY, Niu Y, Nan Y. Molecular mechanisms of Buqing granule for the treatment of diabetic retinopathy: Network pharmacology analysis and experimental validation. <i>World J Diabetes</i> 2024; 15(9): 1942-1961</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v15/i9/1942.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v15.i9.1942 |
