| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Curcumin for gastric cancer: Mechanism prediction via network pharmacology, docking, and in vitro experiments
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Peng-Hui Yang, Ya-Nan Wei, Bi-Juan Xiao, Si-Yi Li, Xin-Long Li, Liang-Jun Yang, Hua-Feng Pan and Geng-Xin Chen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Nature Science Foundation of China |
81273735 and 82174319 |
| the Natural Science Foundation of Guangdong Province, China |
2021A1515010961 |
| the Key-Area Research and Development Program of Guangdong Province, China |
2020B1111100011 |
| the China Postdoctoral Science Foundation, China |
2023M740859 |
|
| Corresponding Author |
Geng-Xin Chen, MD, Chief Doctor, Centre for Translational Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111 Dade Road, Guangzhou 510120, Guangdong Province, China. gxchen@gzucm.edu.cn |
| Key Words |
Curcumin; Gastric cancer; Network pharmacology; Molecular docking; Survival analysis |
| Core Tip |
This study aimed to elucidate the therapeutic mechanisms of curcumin in gastric cancer (GC). Through network pharmacology, core targets correlating to poor survival in patients with GC were identified, including estrogen receptor 1 (ESR1), epidermal growth factor receptor (EGFR), cytochrome P450 family 3 subfamily A member 4 (CYP3A4), mitogen-activated protein kinase 14 (MAPK14), cytochrome P450 family 1 subfamily A member 2 (CYP1A2), and cytochrome p450 family 2 subfamily B member 6 (CYP2B6). Molecular docking confirmed the favorable interactions of curcumin with pivotal target genes. In vitro experiments validated the regulatory effects of curcumin on GC cells through these targets. The therapeutic efficacy of curcumin involves multitarget, multipathway, and multibiological processes, offering new insights into its clinical application in GC treatment. |
| Publish Date |
2024-08-08 04:58 |
| Citation |
<p>Yang PH, Wei YN, Xiao BJ, Li SY, Li XL, Yang LJ, Pan HF, Chen GX. Curcumin for gastric cancer: Mechanism prediction via network pharmacology, docking, and in vitro experiments. <i>World J Gastrointest Oncol</i> 2024; 16(8): 3635-3650</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i8/3635.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i8.3635 |
